Abstract
Annual administration of the seasonal influenza vaccine is strongly recommended to reduce the burden of disease, particularly for persons at the highest risk for the viral infection. Even during years when there is a good match between the vaccine and circulating strains, host-related factors such as age, preexisting immunity, genetic polymorphisms, and the presence of chronic underlying conditions may compromise influenza vaccine responsiveness. The application of new methodologies and large-scale profiling technologies are improving the ability to measure vaccine immunogenicity and our understanding of the immune mechanisms by which vaccines induce protective immunity. This review attempts to summarize the general concepts of how host factors can contribute to the heterogeneity of immune responses induced by influenza vaccines.
| Original language | English |
|---|---|
| Pages (from-to) | 637-646 |
| Number of pages | 10 |
| Journal | Human Vaccines and Immunotherapeutics |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 4 2018 |
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Keywords
- aging
- genetic polymorphism
- immune response
- immunocompromised
- influenza vaccine
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pharmacology
Cite this
Factors affecting immune responses to the influenza vaccine. / Castrucci, Maria R.
In: Human Vaccines and Immunotherapeutics, Vol. 14, No. 3, 04.03.2018, p. 637-646.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Factors affecting immune responses to the influenza vaccine
AU - Castrucci, Maria R.
PY - 2018/3/4
Y1 - 2018/3/4
N2 - Annual administration of the seasonal influenza vaccine is strongly recommended to reduce the burden of disease, particularly for persons at the highest risk for the viral infection. Even during years when there is a good match between the vaccine and circulating strains, host-related factors such as age, preexisting immunity, genetic polymorphisms, and the presence of chronic underlying conditions may compromise influenza vaccine responsiveness. The application of new methodologies and large-scale profiling technologies are improving the ability to measure vaccine immunogenicity and our understanding of the immune mechanisms by which vaccines induce protective immunity. This review attempts to summarize the general concepts of how host factors can contribute to the heterogeneity of immune responses induced by influenza vaccines.
AB - Annual administration of the seasonal influenza vaccine is strongly recommended to reduce the burden of disease, particularly for persons at the highest risk for the viral infection. Even during years when there is a good match between the vaccine and circulating strains, host-related factors such as age, preexisting immunity, genetic polymorphisms, and the presence of chronic underlying conditions may compromise influenza vaccine responsiveness. The application of new methodologies and large-scale profiling technologies are improving the ability to measure vaccine immunogenicity and our understanding of the immune mechanisms by which vaccines induce protective immunity. This review attempts to summarize the general concepts of how host factors can contribute to the heterogeneity of immune responses induced by influenza vaccines.
KW - aging
KW - genetic polymorphism
KW - immune response
KW - immunocompromised
KW - influenza vaccine
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U2 - 10.1080/21645515.2017.1338547
DO - 10.1080/21645515.2017.1338547
M3 - Review article
VL - 14
SP - 637
EP - 646
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
SN - 2164-5515
IS - 3
ER -