Factors affecting response and survival in advanced head and neck cancers treated with intraarterial chemotherapy

F. Claudio, M. Rotondi, S. Bonassi, F. Cacace, G. Comella, F. Coucourde, P. P. Claudio, A. M. Bevilacqua, F. Ionna, S. Toma

Research output: Contribution to journalArticlepeer-review

Abstract

This paper reports several prognostic parameters in advanced unresectable head and neck cancers submitted to intraarterial administration of vincristine, bleomycin and methotrexate or cisplatin and bleomycin. Forty previously untreated patients entered the study; 39 were considered evaluable for clinical response and survival; 23 were evaluated for pathological response. An objective clinical response was obtained in 76.9%, which included a 12.8% complete response. A pathological complete response was obtained in 56.5% of the cases. The overall 1-year and 2-year survival of the whole group of patients was 72.5% and 50% respectively. Logistic regression analysis demonstrated that none of the prognostic factors considered was significant for clinical response; on the other hand, the pathological response was found to be significantly related to age. In regard to survival the objective clinical response and the lymph node status were the prognostic parameters that attained statistical significance in the Cox regression analysis (P <0.02 and P <0.003 respectively) even if performance status and pathological response do seem to improve survival.

Original languageEnglish
Pages (from-to)180-187
Number of pages8
JournalRegional Cancer Treatment
Volume4
Issue number4
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

Fingerprint

Dive into the research topics of 'Factors affecting response and survival in advanced head and neck cancers treated with intraarterial chemotherapy'. Together they form a unique fingerprint.

Cite this