Factors affecting 18F FDOPA standardized uptake value in patients with primary brain tumors after treatment

Agostino Chiaravalloti, Alessandro Fiorentini, Veronica Villani, Carmine Carapella, Andrea Pace, Barbara Di Pietro, Carmen Di Russo, Barbara Palumbo, Roberto Floris, Orazio Schillaci

Research output: Contribution to journalArticle

Abstract

Aim: To investigate the factors affecting 18F FDOPA uptake in patients with primary brain tumors (PBT) after treatment. Materials and methods: 97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent 18F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively. Results: 18F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade. Conclusions: The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect 18F FDOPA uptake.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalNuclear Medicine and Biology
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • F FDOPA
  • Chemotherapy
  • Primary brain tumors
  • Radiotherapy
  • Surgery
  • SUV

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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