Abstract
Aims: Prognostic analysis of hepatocellular carcinoma (HCC) in the cirrhotic patient undergoing hepatic resection is necessary in order to determine the clinical effect of hepatectomy on prognosis. Patients and methods: Univariate and multivariate retrospective analyses were performed in 51 cirrhotic patients (38 men, 13 women; mean age 65 years, range 43-81 years) with supervening HCC undergoing hepatic resection between January 1993 and December 1997. Results: Segmental liver resection was performed in 39 patients (76%) with non-anatomical (wedge) resections in the remainder of cases. The post-operative mortality rate was 8%. The tumours recurred in 23 patients (45%), with 12 patients (52% of recurrences) recurring within 1 year of surgery and 22 patients (96% of recurrences) within 3 years. Recurrent disease was most frequently intrahepatic (22 patients). Significant risk factors for recurrence were micro/ macro vascular invasion, and symptoms. Conclusions: The recurrence rate of hepatocellular carcinoma in patients with cirrhosis undergoing surgical resection alone is high and actuarial survival at 4 years is low. Other approaches to the treatment of hepatocellular carcinoma in patients with cirrhosis require consideration. (C) 2000 Harcourt Publishers Ltd.
Original language | English |
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Pages (from-to) | 387-392 |
Number of pages | 6 |
Journal | European Journal of Surgical Oncology |
Volume | 26 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jun 2000 |
Keywords
- Cirrhosis
- Disease-free survival
- Hepatic resections
- Hepatocellular carcinoma
- Prognostic factors
- Survival
ASJC Scopus subject areas
- Oncology
- Surgery