Factors affecting survival and long-term outcome in the cirrhotic patient undergoing hepatic resection for hepatocellular carcinoma

A. Chiappa, A. P. Zbar, R. A. Audisio, B. E. Leone, F. Biella, C. Staudacher

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Aims: Prognostic analysis of hepatocellular carcinoma (HCC) in the cirrhotic patient undergoing hepatic resection is necessary in order to determine the clinical effect of hepatectomy on prognosis. Patients and methods: Univariate and multivariate retrospective analyses were performed in 51 cirrhotic patients (38 men, 13 women; mean age 65 years, range 43-81 years) with supervening HCC undergoing hepatic resection between January 1993 and December 1997. Results: Segmental liver resection was performed in 39 patients (76%) with non-anatomical (wedge) resections in the remainder of cases. The post-operative mortality rate was 8%. The tumours recurred in 23 patients (45%), with 12 patients (52% of recurrences) recurring within 1 year of surgery and 22 patients (96% of recurrences) within 3 years. Recurrent disease was most frequently intrahepatic (22 patients). Significant risk factors for recurrence were micro/ macro vascular invasion, and symptoms. Conclusions: The recurrence rate of hepatocellular carcinoma in patients with cirrhosis undergoing surgical resection alone is high and actuarial survival at 4 years is low. Other approaches to the treatment of hepatocellular carcinoma in patients with cirrhosis require consideration. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume26
Issue number4
DOIs
Publication statusPublished - Jun 2000

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Hepatocellular Carcinoma
Survival
Liver
Recurrence
Fibrosis
Hepatectomy
Blood Vessels
Multivariate Analysis
Mortality

Keywords

  • Cirrhosis
  • Disease-free survival
  • Hepatic resections
  • Hepatocellular carcinoma
  • Prognostic factors
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Factors affecting survival and long-term outcome in the cirrhotic patient undergoing hepatic resection for hepatocellular carcinoma. / Chiappa, A.; Zbar, A. P.; Audisio, R. A.; Leone, B. E.; Biella, F.; Staudacher, C.

In: European Journal of Surgical Oncology, Vol. 26, No. 4, 06.2000, p. 387-392.

Research output: Contribution to journalArticle

Chiappa, A. ; Zbar, A. P. ; Audisio, R. A. ; Leone, B. E. ; Biella, F. ; Staudacher, C. / Factors affecting survival and long-term outcome in the cirrhotic patient undergoing hepatic resection for hepatocellular carcinoma. In: European Journal of Surgical Oncology. 2000 ; Vol. 26, No. 4. pp. 387-392.
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