Abstract
Aims: Prognostic analysis of hepatocellular carcinoma (HCC) in the cirrhotic patient undergoing hepatic resection is necessary in order to determine the clinical effect of hepatectomy on prognosis. Patients and methods: Univariate and multivariate retrospective analyses were performed in 51 cirrhotic patients (38 men, 13 women; mean age 65 years, range 43-81 years) with supervening HCC undergoing hepatic resection between January 1993 and December 1997. Results: Segmental liver resection was performed in 39 patients (76%) with non-anatomical (wedge) resections in the remainder of cases. The post-operative mortality rate was 8%. The tumours recurred in 23 patients (45%), with 12 patients (52% of recurrences) recurring within 1 year of surgery and 22 patients (96% of recurrences) within 3 years. Recurrent disease was most frequently intrahepatic (22 patients). Significant risk factors for recurrence were micro/ macro vascular invasion, and symptoms. Conclusions: The recurrence rate of hepatocellular carcinoma in patients with cirrhosis undergoing surgical resection alone is high and actuarial survival at 4 years is low. Other approaches to the treatment of hepatocellular carcinoma in patients with cirrhosis require consideration. (C) 2000 Harcourt Publishers Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 387-392 |
| Number of pages | 6 |
| Journal | European Journal of Surgical Oncology |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jun 2000 |
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Keywords
- Cirrhosis
- Disease-free survival
- Hepatic resections
- Hepatocellular carcinoma
- Prognostic factors
- Survival
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Factors affecting survival and long-term outcome in the cirrhotic patient undergoing hepatic resection for hepatocellular carcinoma. / Chiappa, A.; Zbar, A. P.; Audisio, R. A.; Leone, B. E.; Biella, F.; Staudacher, C.
In: European Journal of Surgical Oncology, Vol. 26, No. 4, 06.2000, p. 387-392.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors affecting survival and long-term outcome in the cirrhotic patient undergoing hepatic resection for hepatocellular carcinoma
AU - Chiappa, A.
AU - Zbar, A. P.
AU - Audisio, R. A.
AU - Leone, B. E.
AU - Biella, F.
AU - Staudacher, C.
PY - 2000/6
Y1 - 2000/6
N2 - Aims: Prognostic analysis of hepatocellular carcinoma (HCC) in the cirrhotic patient undergoing hepatic resection is necessary in order to determine the clinical effect of hepatectomy on prognosis. Patients and methods: Univariate and multivariate retrospective analyses were performed in 51 cirrhotic patients (38 men, 13 women; mean age 65 years, range 43-81 years) with supervening HCC undergoing hepatic resection between January 1993 and December 1997. Results: Segmental liver resection was performed in 39 patients (76%) with non-anatomical (wedge) resections in the remainder of cases. The post-operative mortality rate was 8%. The tumours recurred in 23 patients (45%), with 12 patients (52% of recurrences) recurring within 1 year of surgery and 22 patients (96% of recurrences) within 3 years. Recurrent disease was most frequently intrahepatic (22 patients). Significant risk factors for recurrence were micro/ macro vascular invasion, and symptoms. Conclusions: The recurrence rate of hepatocellular carcinoma in patients with cirrhosis undergoing surgical resection alone is high and actuarial survival at 4 years is low. Other approaches to the treatment of hepatocellular carcinoma in patients with cirrhosis require consideration. (C) 2000 Harcourt Publishers Ltd.
AB - Aims: Prognostic analysis of hepatocellular carcinoma (HCC) in the cirrhotic patient undergoing hepatic resection is necessary in order to determine the clinical effect of hepatectomy on prognosis. Patients and methods: Univariate and multivariate retrospective analyses were performed in 51 cirrhotic patients (38 men, 13 women; mean age 65 years, range 43-81 years) with supervening HCC undergoing hepatic resection between January 1993 and December 1997. Results: Segmental liver resection was performed in 39 patients (76%) with non-anatomical (wedge) resections in the remainder of cases. The post-operative mortality rate was 8%. The tumours recurred in 23 patients (45%), with 12 patients (52% of recurrences) recurring within 1 year of surgery and 22 patients (96% of recurrences) within 3 years. Recurrent disease was most frequently intrahepatic (22 patients). Significant risk factors for recurrence were micro/ macro vascular invasion, and symptoms. Conclusions: The recurrence rate of hepatocellular carcinoma in patients with cirrhosis undergoing surgical resection alone is high and actuarial survival at 4 years is low. Other approaches to the treatment of hepatocellular carcinoma in patients with cirrhosis require consideration. (C) 2000 Harcourt Publishers Ltd.
KW - Cirrhosis
KW - Disease-free survival
KW - Hepatic resections
KW - Hepatocellular carcinoma
KW - Prognostic factors
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=0033924934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033924934&partnerID=8YFLogxK
U2 - 10.1053/ejso.1999.0904
DO - 10.1053/ejso.1999.0904
M3 - Article
C2 - 10873361
AN - SCOPUS:0033924934
VL - 26
SP - 387
EP - 392
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 4
ER -