Factors associated with inflammation markers, a cross-sectional analysis

Tess V. Clendenen, Karen L. Koenig, Alan A. Arslan, Annekatrin Lukanova, Franco Berrino, Yian Gu, Goran Hallmans, Annika Idahl, Vittorio Krogh, Anna E. Lokshin, Eva Lundin, Paola Muti, Adele Marrangoni, Brian M. Nolen, Nina Ohlson, Roy E. Shore, Sabina Sieri, Anne Zeleniuch-Jacquotte

Research output: Contribution to journalArticle

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Abstract

Epidemiological studies have reported associations between circulating inflammation markers and risk of chronic diseases. It is of interest to examine whether risk factors for these diseases are associated with inflammation. We conducted a cross-sectional analysis to evaluate whether reproductive and lifestyle factors and circulating vitamin D were associated with inflammation markers, including C-reactive protein, cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα), and cytokine modulators (IL-1RA, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1/R2), among 616 healthy women. We confirmed associations of several inflammation markers with age and BMI. We also observed significantly higher levels of certain inflammation markers in postmenopausal vs. premenopausal women (TNFα, sIL-1RII, sIL-2Ra), with increasing parity (IL-12p40), and with higher circulating 25(OH) vitamin D (IL-13) and lower levels among current users of non-steroidal anti-inflammatory drugs (NSAIDs) (IL-1β, IL-2, IL-10, IL-12p70, and IL-12p40), current smokers (IL-4, IL-13, IL-12p40), and women with a family history of breast or ovarian cancer (IL-4, IL-10, IL-13). Our findings suggest that risk factors for chronic diseases (age, BMI, menopausal status, parity, NSAID use, family history of breast and ovarian cancer, and smoking) are associated with inflammation markers in healthy women.

Original languageEnglish
Pages (from-to)769-778
Number of pages10
JournalCytokine
Volume56
Issue number3
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Interleukin-12 Subunit p40
Interleukin-13
Cross-Sectional Studies
Inflammation
Interleukin-10
Parity
Interleukin-1
Vitamin D
Ovarian Neoplasms
Interleukin-2
Chronic Disease
Anti-Inflammatory Agents
Breast Neoplasms
Cytokines
Interleukin-5
Pharmaceutical Preparations
C-Reactive Protein
Modulators
Life Style
Epidemiologic Studies

Keywords

  • C-reactive protein
  • Cross-sectional studies
  • Cytokine receptors
  • Cytokines
  • Epidemiologic factors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Clendenen, T. V., Koenig, K. L., Arslan, A. A., Lukanova, A., Berrino, F., Gu, Y., ... Zeleniuch-Jacquotte, A. (2011). Factors associated with inflammation markers, a cross-sectional analysis. Cytokine, 56(3), 769-778. https://doi.org/10.1016/j.cyto.2011.09.013

Factors associated with inflammation markers, a cross-sectional analysis. / Clendenen, Tess V.; Koenig, Karen L.; Arslan, Alan A.; Lukanova, Annekatrin; Berrino, Franco; Gu, Yian; Hallmans, Goran; Idahl, Annika; Krogh, Vittorio; Lokshin, Anna E.; Lundin, Eva; Muti, Paola; Marrangoni, Adele; Nolen, Brian M.; Ohlson, Nina; Shore, Roy E.; Sieri, Sabina; Zeleniuch-Jacquotte, Anne.

In: Cytokine, Vol. 56, No. 3, 12.2011, p. 769-778.

Research output: Contribution to journalArticle

Clendenen, TV, Koenig, KL, Arslan, AA, Lukanova, A, Berrino, F, Gu, Y, Hallmans, G, Idahl, A, Krogh, V, Lokshin, AE, Lundin, E, Muti, P, Marrangoni, A, Nolen, BM, Ohlson, N, Shore, RE, Sieri, S & Zeleniuch-Jacquotte, A 2011, 'Factors associated with inflammation markers, a cross-sectional analysis', Cytokine, vol. 56, no. 3, pp. 769-778. https://doi.org/10.1016/j.cyto.2011.09.013
Clendenen TV, Koenig KL, Arslan AA, Lukanova A, Berrino F, Gu Y et al. Factors associated with inflammation markers, a cross-sectional analysis. Cytokine. 2011 Dec;56(3):769-778. https://doi.org/10.1016/j.cyto.2011.09.013
Clendenen, Tess V. ; Koenig, Karen L. ; Arslan, Alan A. ; Lukanova, Annekatrin ; Berrino, Franco ; Gu, Yian ; Hallmans, Goran ; Idahl, Annika ; Krogh, Vittorio ; Lokshin, Anna E. ; Lundin, Eva ; Muti, Paola ; Marrangoni, Adele ; Nolen, Brian M. ; Ohlson, Nina ; Shore, Roy E. ; Sieri, Sabina ; Zeleniuch-Jacquotte, Anne. / Factors associated with inflammation markers, a cross-sectional analysis. In: Cytokine. 2011 ; Vol. 56, No. 3. pp. 769-778.
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