Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice

Eliane Gluckman, Vanderson Rocha, William Arcese, Gérard Michel, Guillermo Sanz, Ka Wah Chan, Tsuneo A. Takahashi, Juan Ortega, Alexandra Filipovich, Franco Locatelli, Shigetaka Asano, Franca Fagioli, Marcus Vowels, Anne Sirvent, Jean Philippe Laporte, Karin Tiedemann, Sergio Amadori, Manuel Abecassis, Pierre Bordigoni, Blanca DiezPeter J. Shaw, Ajay Vora, Maurizio Caniglia, Federico Garnier, Irina Ionescu, Joan Garcia, Gesine Koegler, Paolo Rebulla, Sylvie Chevret

Research output: Contribution to journalArticle

331 Citations (Scopus)

Abstract

Objective Optimizing cord blood donor selection based mainly on cell dose and human leukocyte antigen (HLA) disparities may further improve results of unrelated cord blood transplants (UCBT). Materials and results We analyzed 550 UCBTs for hematologic malignancies reported to the Eurocord Registry. Main outcomes and prognostic factors were analyzed in univariable and multivariable analyses incorporating center and period effects and using death and relapse as competitive risks for nonfatal endpoints. Nucleated cell (NC) dose before freezing and number of HLA disparities had a significant influence on outcome. Cumulative incidence (CI) of neutrophil and platelet recovery was associated with the number of HLA mismatches, number of NC before freezing, and use of granulocyte colony-stimulating factor. Coexistence of HLA class I and II disparities and high CD34 cell dose in the graft were associated with graft-vs-host disease grades III-IV. CI of disease relapse was higher in matched transplants showing a graft-vs-leukemia effect increased in HLA-mismatched transplants. Overall 3-year survival was 34.4%. Prognostic factors for survival were recipient age, gender, and disease status. Conclusion Our results provide indications for a better choice of cord blood units according to cord blood cell content and HLA.

Original languageEnglish
Pages (from-to)397-407
Number of pages11
JournalExperimental Hematology
Volume32
Issue number4
DOIs
Publication statusPublished - Apr 2004

Fingerprint

HLA Antigens
Fetal Blood
Tissue Donors
Guidelines
Transplants
Freezing
Graft vs Leukemia Effect
Donor Selection
Recurrence
Incidence
Graft vs Host Disease
Granulocyte Colony-Stimulating Factor
Hematologic Neoplasms
Blood Donors
Registries
Blood Cells
Neutrophils
Blood Platelets
Cell Count

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Gluckman, E., Rocha, V., Arcese, W., Michel, G., Sanz, G., Chan, K. W., ... Chevret, S. (2004). Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice. Experimental Hematology, 32(4), 397-407. https://doi.org/10.1016/j.exphem.2004.01.002

Factors associated with outcomes of unrelated cord blood transplant : Guidelines for donor choice. / Gluckman, Eliane; Rocha, Vanderson; Arcese, William; Michel, Gérard; Sanz, Guillermo; Chan, Ka Wah; Takahashi, Tsuneo A.; Ortega, Juan; Filipovich, Alexandra; Locatelli, Franco; Asano, Shigetaka; Fagioli, Franca; Vowels, Marcus; Sirvent, Anne; Laporte, Jean Philippe; Tiedemann, Karin; Amadori, Sergio; Abecassis, Manuel; Bordigoni, Pierre; Diez, Blanca; Shaw, Peter J.; Vora, Ajay; Caniglia, Maurizio; Garnier, Federico; Ionescu, Irina; Garcia, Joan; Koegler, Gesine; Rebulla, Paolo; Chevret, Sylvie.

In: Experimental Hematology, Vol. 32, No. 4, 04.2004, p. 397-407.

Research output: Contribution to journalArticle

Gluckman, E, Rocha, V, Arcese, W, Michel, G, Sanz, G, Chan, KW, Takahashi, TA, Ortega, J, Filipovich, A, Locatelli, F, Asano, S, Fagioli, F, Vowels, M, Sirvent, A, Laporte, JP, Tiedemann, K, Amadori, S, Abecassis, M, Bordigoni, P, Diez, B, Shaw, PJ, Vora, A, Caniglia, M, Garnier, F, Ionescu, I, Garcia, J, Koegler, G, Rebulla, P & Chevret, S 2004, 'Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice', Experimental Hematology, vol. 32, no. 4, pp. 397-407. https://doi.org/10.1016/j.exphem.2004.01.002
Gluckman, Eliane ; Rocha, Vanderson ; Arcese, William ; Michel, Gérard ; Sanz, Guillermo ; Chan, Ka Wah ; Takahashi, Tsuneo A. ; Ortega, Juan ; Filipovich, Alexandra ; Locatelli, Franco ; Asano, Shigetaka ; Fagioli, Franca ; Vowels, Marcus ; Sirvent, Anne ; Laporte, Jean Philippe ; Tiedemann, Karin ; Amadori, Sergio ; Abecassis, Manuel ; Bordigoni, Pierre ; Diez, Blanca ; Shaw, Peter J. ; Vora, Ajay ; Caniglia, Maurizio ; Garnier, Federico ; Ionescu, Irina ; Garcia, Joan ; Koegler, Gesine ; Rebulla, Paolo ; Chevret, Sylvie. / Factors associated with outcomes of unrelated cord blood transplant : Guidelines for donor choice. In: Experimental Hematology. 2004 ; Vol. 32, No. 4. pp. 397-407.
@article{9f90ca1a77b941a98acdb7f15e52842a,
title = "Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice",
abstract = "Objective Optimizing cord blood donor selection based mainly on cell dose and human leukocyte antigen (HLA) disparities may further improve results of unrelated cord blood transplants (UCBT). Materials and results We analyzed 550 UCBTs for hematologic malignancies reported to the Eurocord Registry. Main outcomes and prognostic factors were analyzed in univariable and multivariable analyses incorporating center and period effects and using death and relapse as competitive risks for nonfatal endpoints. Nucleated cell (NC) dose before freezing and number of HLA disparities had a significant influence on outcome. Cumulative incidence (CI) of neutrophil and platelet recovery was associated with the number of HLA mismatches, number of NC before freezing, and use of granulocyte colony-stimulating factor. Coexistence of HLA class I and II disparities and high CD34 cell dose in the graft were associated with graft-vs-host disease grades III-IV. CI of disease relapse was higher in matched transplants showing a graft-vs-leukemia effect increased in HLA-mismatched transplants. Overall 3-year survival was 34.4{\%}. Prognostic factors for survival were recipient age, gender, and disease status. Conclusion Our results provide indications for a better choice of cord blood units according to cord blood cell content and HLA.",
author = "Eliane Gluckman and Vanderson Rocha and William Arcese and G{\'e}rard Michel and Guillermo Sanz and Chan, {Ka Wah} and Takahashi, {Tsuneo A.} and Juan Ortega and Alexandra Filipovich and Franco Locatelli and Shigetaka Asano and Franca Fagioli and Marcus Vowels and Anne Sirvent and Laporte, {Jean Philippe} and Karin Tiedemann and Sergio Amadori and Manuel Abecassis and Pierre Bordigoni and Blanca Diez and Shaw, {Peter J.} and Ajay Vora and Maurizio Caniglia and Federico Garnier and Irina Ionescu and Joan Garcia and Gesine Koegler and Paolo Rebulla and Sylvie Chevret",
year = "2004",
month = "4",
doi = "10.1016/j.exphem.2004.01.002",
language = "English",
volume = "32",
pages = "397--407",
journal = "Experimental Hematology",
issn = "0301-472X",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Factors associated with outcomes of unrelated cord blood transplant

T2 - Guidelines for donor choice

AU - Gluckman, Eliane

AU - Rocha, Vanderson

AU - Arcese, William

AU - Michel, Gérard

AU - Sanz, Guillermo

AU - Chan, Ka Wah

AU - Takahashi, Tsuneo A.

AU - Ortega, Juan

AU - Filipovich, Alexandra

AU - Locatelli, Franco

AU - Asano, Shigetaka

AU - Fagioli, Franca

AU - Vowels, Marcus

AU - Sirvent, Anne

AU - Laporte, Jean Philippe

AU - Tiedemann, Karin

AU - Amadori, Sergio

AU - Abecassis, Manuel

AU - Bordigoni, Pierre

AU - Diez, Blanca

AU - Shaw, Peter J.

AU - Vora, Ajay

AU - Caniglia, Maurizio

AU - Garnier, Federico

AU - Ionescu, Irina

AU - Garcia, Joan

AU - Koegler, Gesine

AU - Rebulla, Paolo

AU - Chevret, Sylvie

PY - 2004/4

Y1 - 2004/4

N2 - Objective Optimizing cord blood donor selection based mainly on cell dose and human leukocyte antigen (HLA) disparities may further improve results of unrelated cord blood transplants (UCBT). Materials and results We analyzed 550 UCBTs for hematologic malignancies reported to the Eurocord Registry. Main outcomes and prognostic factors were analyzed in univariable and multivariable analyses incorporating center and period effects and using death and relapse as competitive risks for nonfatal endpoints. Nucleated cell (NC) dose before freezing and number of HLA disparities had a significant influence on outcome. Cumulative incidence (CI) of neutrophil and platelet recovery was associated with the number of HLA mismatches, number of NC before freezing, and use of granulocyte colony-stimulating factor. Coexistence of HLA class I and II disparities and high CD34 cell dose in the graft were associated with graft-vs-host disease grades III-IV. CI of disease relapse was higher in matched transplants showing a graft-vs-leukemia effect increased in HLA-mismatched transplants. Overall 3-year survival was 34.4%. Prognostic factors for survival were recipient age, gender, and disease status. Conclusion Our results provide indications for a better choice of cord blood units according to cord blood cell content and HLA.

AB - Objective Optimizing cord blood donor selection based mainly on cell dose and human leukocyte antigen (HLA) disparities may further improve results of unrelated cord blood transplants (UCBT). Materials and results We analyzed 550 UCBTs for hematologic malignancies reported to the Eurocord Registry. Main outcomes and prognostic factors were analyzed in univariable and multivariable analyses incorporating center and period effects and using death and relapse as competitive risks for nonfatal endpoints. Nucleated cell (NC) dose before freezing and number of HLA disparities had a significant influence on outcome. Cumulative incidence (CI) of neutrophil and platelet recovery was associated with the number of HLA mismatches, number of NC before freezing, and use of granulocyte colony-stimulating factor. Coexistence of HLA class I and II disparities and high CD34 cell dose in the graft were associated with graft-vs-host disease grades III-IV. CI of disease relapse was higher in matched transplants showing a graft-vs-leukemia effect increased in HLA-mismatched transplants. Overall 3-year survival was 34.4%. Prognostic factors for survival were recipient age, gender, and disease status. Conclusion Our results provide indications for a better choice of cord blood units according to cord blood cell content and HLA.

UR - http://www.scopus.com/inward/record.url?scp=12144287126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144287126&partnerID=8YFLogxK

U2 - 10.1016/j.exphem.2004.01.002

DO - 10.1016/j.exphem.2004.01.002

M3 - Article

C2 - 15050751

AN - SCOPUS:12144287126

VL - 32

SP - 397

EP - 407

JO - Experimental Hematology

JF - Experimental Hematology

SN - 0301-472X

IS - 4

ER -