Factors associated with poor health-related quality of life of patients with cirrhosis

Giulio Marchesini, Giampaolo Bianchi, Piero Amodio, Francesco Salerno, Manuela Merli, Carmine Panella, Carmela Loguercio, Giovanni Apolone, Mauro Niero, Roberto Abbiati

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

Background and Aims: Increasing interest is being given to health-related quality of life in chronic diseases. In cirrhosis, both physical functioning and mental well-being may be altered, but no study has investigated factors associated with a poor perceived health status. Methods: We measured quality of life by Short Form-36 and Nottingham Health Profile questionnaires in 544 patients with cirrhosis. Data were compared with age- and gender-adjusted values of 2 random samples of the Italian population (more than 2000 subjects). Factors associated with poor perceived health status were identified by logistic regression. Results: All domains of health-related quality of life, except pain, were altered in cirrhosis (by 9%-42%), mainly in younger patients. There were minor differences in relation to gender, whereas etiology had no effects. Severity of disease (Child-Pugh score) and, above all, muscle cramps were the factors most closely associated with poor health status perception. Self-rating of disease progression was associated with ascites and pruritus, whereas previous variceal sclerotherapy and the use of disaccharides had a protective effect. Most areas of daily life were affected by perceived health problems; this was mainly true for paid employment and sex life in men and home life and social life in women. Conclusions: Quality of life is variably impaired in cirrhosis, also in uncomplicated patients. Non-life-threatening symptoms, such as muscle cramps, are of major concern. These data are the basis for longitudinal studies measuring the effects of therapy and procedures on patient-derived health outcomes.

Original languageEnglish
Pages (from-to)170-178
Number of pages9
JournalGastroenterology
Volume120
Issue number1
Publication statusPublished - 2001

Fingerprint

Fibrosis
Quality of Life
Health Status
Muscle Cramp
Health
Sclerotherapy
Disaccharides
Pruritus
Interpersonal Relations
Ascites
Longitudinal Studies
Disease Progression
Chronic Disease
Logistic Models
Pain
Population
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Marchesini, G., Bianchi, G., Amodio, P., Salerno, F., Merli, M., Panella, C., ... Abbiati, R. (2001). Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology, 120(1), 170-178.

Factors associated with poor health-related quality of life of patients with cirrhosis. / Marchesini, Giulio; Bianchi, Giampaolo; Amodio, Piero; Salerno, Francesco; Merli, Manuela; Panella, Carmine; Loguercio, Carmela; Apolone, Giovanni; Niero, Mauro; Abbiati, Roberto.

In: Gastroenterology, Vol. 120, No. 1, 2001, p. 170-178.

Research output: Contribution to journalArticle

Marchesini, G, Bianchi, G, Amodio, P, Salerno, F, Merli, M, Panella, C, Loguercio, C, Apolone, G, Niero, M & Abbiati, R 2001, 'Factors associated with poor health-related quality of life of patients with cirrhosis', Gastroenterology, vol. 120, no. 1, pp. 170-178.
Marchesini G, Bianchi G, Amodio P, Salerno F, Merli M, Panella C et al. Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology. 2001;120(1):170-178.
Marchesini, Giulio ; Bianchi, Giampaolo ; Amodio, Piero ; Salerno, Francesco ; Merli, Manuela ; Panella, Carmine ; Loguercio, Carmela ; Apolone, Giovanni ; Niero, Mauro ; Abbiati, Roberto. / Factors associated with poor health-related quality of life of patients with cirrhosis. In: Gastroenterology. 2001 ; Vol. 120, No. 1. pp. 170-178.
@article{8a605411b4eb47888d3d827d0d9ad8e5,
title = "Factors associated with poor health-related quality of life of patients with cirrhosis",
abstract = "Background and Aims: Increasing interest is being given to health-related quality of life in chronic diseases. In cirrhosis, both physical functioning and mental well-being may be altered, but no study has investigated factors associated with a poor perceived health status. Methods: We measured quality of life by Short Form-36 and Nottingham Health Profile questionnaires in 544 patients with cirrhosis. Data were compared with age- and gender-adjusted values of 2 random samples of the Italian population (more than 2000 subjects). Factors associated with poor perceived health status were identified by logistic regression. Results: All domains of health-related quality of life, except pain, were altered in cirrhosis (by 9{\%}-42{\%}), mainly in younger patients. There were minor differences in relation to gender, whereas etiology had no effects. Severity of disease (Child-Pugh score) and, above all, muscle cramps were the factors most closely associated with poor health status perception. Self-rating of disease progression was associated with ascites and pruritus, whereas previous variceal sclerotherapy and the use of disaccharides had a protective effect. Most areas of daily life were affected by perceived health problems; this was mainly true for paid employment and sex life in men and home life and social life in women. Conclusions: Quality of life is variably impaired in cirrhosis, also in uncomplicated patients. Non-life-threatening symptoms, such as muscle cramps, are of major concern. These data are the basis for longitudinal studies measuring the effects of therapy and procedures on patient-derived health outcomes.",
author = "Giulio Marchesini and Giampaolo Bianchi and Piero Amodio and Francesco Salerno and Manuela Merli and Carmine Panella and Carmela Loguercio and Giovanni Apolone and Mauro Niero and Roberto Abbiati",
year = "2001",
language = "English",
volume = "120",
pages = "170--178",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Factors associated with poor health-related quality of life of patients with cirrhosis

AU - Marchesini, Giulio

AU - Bianchi, Giampaolo

AU - Amodio, Piero

AU - Salerno, Francesco

AU - Merli, Manuela

AU - Panella, Carmine

AU - Loguercio, Carmela

AU - Apolone, Giovanni

AU - Niero, Mauro

AU - Abbiati, Roberto

PY - 2001

Y1 - 2001

N2 - Background and Aims: Increasing interest is being given to health-related quality of life in chronic diseases. In cirrhosis, both physical functioning and mental well-being may be altered, but no study has investigated factors associated with a poor perceived health status. Methods: We measured quality of life by Short Form-36 and Nottingham Health Profile questionnaires in 544 patients with cirrhosis. Data were compared with age- and gender-adjusted values of 2 random samples of the Italian population (more than 2000 subjects). Factors associated with poor perceived health status were identified by logistic regression. Results: All domains of health-related quality of life, except pain, were altered in cirrhosis (by 9%-42%), mainly in younger patients. There were minor differences in relation to gender, whereas etiology had no effects. Severity of disease (Child-Pugh score) and, above all, muscle cramps were the factors most closely associated with poor health status perception. Self-rating of disease progression was associated with ascites and pruritus, whereas previous variceal sclerotherapy and the use of disaccharides had a protective effect. Most areas of daily life were affected by perceived health problems; this was mainly true for paid employment and sex life in men and home life and social life in women. Conclusions: Quality of life is variably impaired in cirrhosis, also in uncomplicated patients. Non-life-threatening symptoms, such as muscle cramps, are of major concern. These data are the basis for longitudinal studies measuring the effects of therapy and procedures on patient-derived health outcomes.

AB - Background and Aims: Increasing interest is being given to health-related quality of life in chronic diseases. In cirrhosis, both physical functioning and mental well-being may be altered, but no study has investigated factors associated with a poor perceived health status. Methods: We measured quality of life by Short Form-36 and Nottingham Health Profile questionnaires in 544 patients with cirrhosis. Data were compared with age- and gender-adjusted values of 2 random samples of the Italian population (more than 2000 subjects). Factors associated with poor perceived health status were identified by logistic regression. Results: All domains of health-related quality of life, except pain, were altered in cirrhosis (by 9%-42%), mainly in younger patients. There were minor differences in relation to gender, whereas etiology had no effects. Severity of disease (Child-Pugh score) and, above all, muscle cramps were the factors most closely associated with poor health status perception. Self-rating of disease progression was associated with ascites and pruritus, whereas previous variceal sclerotherapy and the use of disaccharides had a protective effect. Most areas of daily life were affected by perceived health problems; this was mainly true for paid employment and sex life in men and home life and social life in women. Conclusions: Quality of life is variably impaired in cirrhosis, also in uncomplicated patients. Non-life-threatening symptoms, such as muscle cramps, are of major concern. These data are the basis for longitudinal studies measuring the effects of therapy and procedures on patient-derived health outcomes.

UR - http://www.scopus.com/inward/record.url?scp=0035175573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035175573&partnerID=8YFLogxK

M3 - Article

C2 - 11208726

AN - SCOPUS:0035175573

VL - 120

SP - 170

EP - 178

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 1

ER -