Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients

F. Sampogna, J. N. Bouwes Bavinck, M. Pawlita, D. Abeni, C. A. Harwood, C. M. Proby, M. C W Feltkamp, S. Euvrard, L. Naldi, R. E. Neale, I. Nindl, H. Pfister, W. G V Quint, T. Waterboer

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Abstract

Viral skin infections are commonly present in organ transplant recipients (OTR). In this study, we aimed to identify factors associated with human papillomavirus (HPV) infections in OTR. Patients with solid-organ transplants were recruited from the outpatient nephrology and dermatology clinics in five European countries. Only patients with no current or past skin cancer were included in this analysis. Serum samples were analysed for antibodies to the L1 proteins of 26 cutaneous and two genital HPV types from five phylogenetic genera (a, b, c, m and n). The most consistent association was found between recreational sun exposure and the seroprevalence of all tested genera, except a. The antibody presence of any b type was higher among people who had been transplanted at least 23 years prior to participation than in those who had been transplanted for less than 7 years. The prevalence of two c-HPV types (60 and 65) and three b-HPV types (15, 38 and 49) was associated with time since transplantation. The presence of a high number of warts was associated with the presence of any m-PV or n-PV types, and having greater than 50 keratotic skin lesions was almost significantly associated with the presence of antibodies to two or more c-PV. Discrepancies in the results of the present study, as well as in previous reports, may depend on different methodologies and on geographical variations. Our results also indicate that further research with more standardized methods is needed to clarify the role of cutaneous HPV in OTR.

Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalJournal of General Virology
Volume93
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Seroepidemiologic Studies
Transplants
Skin
Antibodies
Gammapapillomavirus
Warts
Papillomavirus Infections
Nephrology
Skin Neoplasms
Solar System
Virus Diseases
Dermatology
Outpatients
Transplantation
Serum
Research
Transplant Recipients
Proteins

ASJC Scopus subject areas

  • Virology

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Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients. / Sampogna, F.; Bouwes Bavinck, J. N.; Pawlita, M.; Abeni, D.; Harwood, C. A.; Proby, C. M.; Feltkamp, M. C W; Euvrard, S.; Naldi, L.; Neale, R. E.; Nindl, I.; Pfister, H.; Quint, W. G V; Waterboer, T.

In: Journal of General Virology, Vol. 93, No. 1, 01.2012, p. 165-174.

Research output: Contribution to journalArticle

Sampogna, F, Bouwes Bavinck, JN, Pawlita, M, Abeni, D, Harwood, CA, Proby, CM, Feltkamp, MCW, Euvrard, S, Naldi, L, Neale, RE, Nindl, I, Pfister, H, Quint, WGV & Waterboer, T 2012, 'Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients', Journal of General Virology, vol. 93, no. 1, pp. 165-174. https://doi.org/10.1099/vir.0.035493-0
Sampogna, F. ; Bouwes Bavinck, J. N. ; Pawlita, M. ; Abeni, D. ; Harwood, C. A. ; Proby, C. M. ; Feltkamp, M. C W ; Euvrard, S. ; Naldi, L. ; Neale, R. E. ; Nindl, I. ; Pfister, H. ; Quint, W. G V ; Waterboer, T. / Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients. In: Journal of General Virology. 2012 ; Vol. 93, No. 1. pp. 165-174.
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