Factors associated with virological success with raltegravir-containing regimens and prevalence of raltegravir-resistance-associated mutations at failure in the ARCA database

S. Rusconi, P. Vitiello, F. Adorni, B. Bruzzone, A. De Luca, V. Micheli, P. Meraviglia, R. Maserati, M. Di Pietro, G. Colao, G. Penco, A. Di Biagio, G. Punzi, L. Monno, M. Zazzi

Research output: Contribution to journalArticle

Abstract

Raltegravir (RAL) is the only licensed human immunodeficiency virus (HIV) integrase inhibitor. The factors associated with the virological response to RAL-containing regimens and the prevalence of integrase mutations associated with RAL failure deserve further investigation. From the Antiretroviral Resistance Cohort Analysis database, we selected triple-class-experienced subjects failing their current treatment with complete treatment history available. Selection criteria included HIV-RNA, CD4 count and HIV genotype within 3 months of RAL initiation. Factors associated with 24-week response were analysed; genotypic sensitivity scores (GSS) and weighted-GSS were evaluated. Virological response was achieved in 74.3% of 105 subjects. Mutations associated with RAL failure were detected in 12/24 subjects with an integrase genotype, with the prevalence of Q148H + G140S. Each extra unit of GSS (p 0.05, OR 2.62; 95% CI 1.00-6.87). was found to be a associated with response. Weighted-GSS had borderline statistical significance (p 0.063, OR 2.04; 95% CI 0.96-4.33) When stratifying for different cut-offs (

Original languageEnglish
Pages (from-to)936-942
Number of pages7
JournalClinical Microbiology and Infection
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 2013

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Keywords

  • Drug resistance
  • Genotype
  • human immunodeficiency virus type 1-1
  • Raltegravir
  • Virological response

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Rusconi, S., Vitiello, P., Adorni, F., Bruzzone, B., De Luca, A., Micheli, V., Meraviglia, P., Maserati, R., Di Pietro, M., Colao, G., Penco, G., Di Biagio, A., Punzi, G., Monno, L., & Zazzi, M. (2013). Factors associated with virological success with raltegravir-containing regimens and prevalence of raltegravir-resistance-associated mutations at failure in the ARCA database. Clinical Microbiology and Infection, 19(10), 936-942. https://doi.org/10.1111/1469-0691.12100