Factors determining the proton T1 relaxivity in solutions containing Gd-DTPA

S. Aime, R. Nano

Research output: Contribution to journalArticlepeer-review


The relaxation times T1 and nuclear Overhauser effects were measured in the 13C nuclear magnetic resonance (NMR) spectra of the diamagnetic calcium (Ca) and lanthanum (La) analogs of Gd-DTPA. From these data the correlation times for the molecular reorientation τ(R) were calculated; it is suggested that this term is the dominant one in the evaluation of the paramagnetic relaxation equation. The similar τ(R) values obtained in water and blood serum ruled out the occurrence of any adduct formation between Gd-DTPA complex and the macromolecular framework in the latter system. The difference in relaxivity shown by Gd-DTPA in the two media is interpreted in terms of influence of the serum components on the dissociation equilibrium of Gd-DTPA.

Original languageEnglish
JournalInvestigative Radiology
Issue numberSUPPL. 1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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