Factors influencing final/near-final height in 12 boys with central precocious puberty treated with gonadotrophin-releasing hormone agonists

V. Rizzo, V. De Sanctis, A. Corrias, M. Fortini, F. Galluzzi, S. Bertelloni, M. P. Guarneri, G. Pozzan, M. Cisternino, A. M. Pasquino

Research output: Contribution to journalArticlepeer-review

Abstract

Gonadotrophin-releasing hormone agonists (GnRHa) have been demonstrated as the therapy of choice for central precocious puberty (CPP). Few studies have provided male patients' adult height data. In our multicenter study we evaluated long-term effects of different GnRHa preparations and final/near-final height (FH) in 12 boys with CPP and analyzed the factors influencing FH. Patients' mean chronological age at the time of diagnosis was 7.6 ± 0.9 yr. Three patients were treated only with triptorelin at a mean dose of 90 μg/kg i.m. every 28 days. Nine patients initially received buserelin (at a mean initial dose of 53.4 μg/kg/day i.n. divided into 3-6 equal doses) or buserelin (at a mean dose of 36.7 μg/kg/day s.c.) and were subsequently switched to triptorelin. The GnRHa therapy was continued for 4.1 ± 0.6 yr (range 2.9-5.4). The mean predicted adult height increased from 169.9 ± 4.2 cm at diagnosis to 180.7 ± 6.0 cm at the end of treatment. Mean FH was 176.1 ± 6.1 cm (170.1-190.7), corresponding to mean SDS(CA) 0.4 ± 0.8 (-0.6/2.5), mean SDS(BA) 0.2 ± 0.9 (-0.6/2.4) and mean corrected SDS for target height of 0.4 ± 0.6 (-0.8/1.2). Multiple regression analysis revealed that FH was mainly influenced by target height and height at discontinuation of GnRHa therapy. The present data indicate that GnRHa therapy significantly improves growth prognosis in boys with CPP and fully restores genetic height potential.

Original languageEnglish
Pages (from-to)781-786
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume13
Issue numberSUPPL. 1
Publication statusPublished - 2000

Keywords

  • Bone age
  • Central precocious puberty
  • Final height
  • GnRH agonists

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

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