TY - JOUR
T1 - Factors influencing oxidative imbalance in pulmonary fibrosis
T2 - An immunohistochemical study
AU - Inghilleri, Simona
AU - Morbini, Patrizia
AU - Campo, Ilaria
AU - Zorzetto, Michele
AU - Oggionni, Tiberio
AU - Pozzi, Ernesto
AU - Luisetti, Maurizio
PY - 2011
Y1 - 2011
N2 - Background. Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease of unknown etiology characterized by interstitial fibrosis determining irreversible distortion of pulmonary architecture. Reactive oxygen species (ROS) and markers of oxidative stress play a pivotal role in human IPF pathology, possibly through induction of epithelial-mesenchymal transition (EMT). Methods. We investigated by immunohistochemistry, in UIP and COP tissue samples, the expression of most relevant markers of the molecular interplay involving RAGE, oxidant/antioxidant balance regulation, tissue nitrosylation, and mediators of EMT. Results. In both UIP and COP, the degree of RAGE expression was similarly high, while SODs and i-NOS, diffusely present in COP endoalveolar plugs, were almost absent in UIP fibroblast foci. A lower degree of tissue nitrosilation was observed in UIP than in COP. Conclusions. Fibroblast lesions of UIP and of COP share a similar degree of activation of RAGE, while antioxidant enzyme expression markedly reduced in UIP. Erratum of Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study dx.doi.org/10.1155/2011/515608
AB - Background. Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease of unknown etiology characterized by interstitial fibrosis determining irreversible distortion of pulmonary architecture. Reactive oxygen species (ROS) and markers of oxidative stress play a pivotal role in human IPF pathology, possibly through induction of epithelial-mesenchymal transition (EMT). Methods. We investigated by immunohistochemistry, in UIP and COP tissue samples, the expression of most relevant markers of the molecular interplay involving RAGE, oxidant/antioxidant balance regulation, tissue nitrosylation, and mediators of EMT. Results. In both UIP and COP, the degree of RAGE expression was similarly high, while SODs and i-NOS, diffusely present in COP endoalveolar plugs, were almost absent in UIP fibroblast foci. A lower degree of tissue nitrosilation was observed in UIP than in COP. Conclusions. Fibroblast lesions of UIP and of COP share a similar degree of activation of RAGE, while antioxidant enzyme expression markedly reduced in UIP. Erratum of Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study dx.doi.org/10.1155/2011/515608
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U2 - 10.1155/2011/421409
DO - 10.1155/2011/421409
M3 - Article
C2 - 21660236
AN - SCOPUS:84876510945
JO - Pulmonary Medicine
JF - Pulmonary Medicine
SN - 2090-1836
M1 - 421409
ER -