Factors influencing psychological well-being in patients with Parkinson’s disease

Alessandra Nicoletti, Giovanni Mostile, Fabrizio Stocchi, Giovanni Abbruzzese, Roberto Ceravolo, Pietro Cortelli, Marco D’Amelio, Maria F. De Pandis, Giovanni Fabbrini, Claudio Pacchetti, Gianni Pezzoli, Alessandro Tessitore, Margherita Canesi, Mario Zappia

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Abstract

Background Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson’s disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale. Objectives To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates. Methods This article reports data of patients’ perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional study conducted in Italian PD patients (FORTE Study). We tested possible relationship between well-being and clinical characteristics including fatigue, depression, sleep disruption and HRQoL. Results 272 patients completed the PWS questionnaire. Significant and clinically-relevant correlations were found between PWS total score and Parkinson’s Fatigue Scale, Beck Depression Inventory, UPDRS Section I, PD Sleep Scale and PDQ-39 for HRQoL scores. Only clinically negligible correlations were found between PWS and motor scores. Conclusions Non-motor symptoms have a significant impact on psychological well-being in PD patients.
Original languageEnglish
Article numbere0189682
JournalPLoS One
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

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Nicoletti, A., Mostile, G., Stocchi, F., Abbruzzese, G., Ceravolo, R., Cortelli, P., D’Amelio, M., De Pandis, M. F., Fabbrini, G., Pacchetti, C., Pezzoli, G., Tessitore, A., Canesi, M., & Zappia, M. (2017). Factors influencing psychological well-being in patients with Parkinson’s disease. PLoS One, 12(12), [e0189682]. https://doi.org/10.1371/journal.pone.0189682