Data of the North Italy Transplant Program, collected in successive periods, were analyzed using both the univariate and multivariate methods of analysis to determine which factors influence the outcome of first cadaver kidney transplants. Treatment with Cy-A, both very young and old age of the donor, and preexisting lymphocytotoxic antibodies in the patient's serum were major factors: the first improved and the other two decreased graft survival. Pretransplant blood transfusion had a major effect in the first period but is no longer evaluable because since 1978 only transfused patients have been admitted to transplantation in the NITp. Both in conventionally treated and Cy-A-treated patients, increasing the number of pretransplant transfusions beyond 3 units of packed red cells adds no further benefit to graft survival but increases the risks of disease transmission and antibody formation, which in turn delays transplantation and has a negative effect on the survival of the transplanted kidney. HLA matching was significant under certain conditions in the univariate but not in the multivariate analysis. A transplant center effect, evident in the first two periods, was no longer significant in Cy-A-treated patients. Age of the recipient also had an effect that disappeared in Cy-A-treated patients. The factors examined did not have a significantly different influence on early and later post-transplant periods, except possibly the age of both donor and recipient.
|Number of pages||6|
|Publication status||Published - 1985|
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