TY - JOUR
T1 - Factors Influencing the Clinical Presentation of Breakthrough Pain in Cancer Patients
AU - IOPS MS study group
AU - Mercadante, Sebastiano
AU - Marchetti, Paolo
AU - Cuomo, Arturo
AU - Caraceni, Augusto
AU - Mediati, Rocco Domenico
AU - Vellucci, Renato
AU - Mammucari, Massimo
AU - Natoli, Silvia
AU - Lazzari, Marzia
AU - Dauri, Mario
AU - Adile, Claudio
AU - Airoldi, Mario
AU - Azzarello, Giuseppe
AU - Bandera, Mauro
AU - Blasi, Livio
AU - Cartenì, Giacomo
AU - Chiurazzi, Bruno
AU - Costanzo, Benedetta Veruska Pierpaola
AU - Degiovanni, Daniela
AU - Fusco, Flavio
AU - Guardamagna, Vittorio
AU - Iaffaioli, Vincenzo
AU - Liguori, Simeone
AU - Palermo, Loredana
AU - Mameli, Sergio
AU - Masedu, Francesco
AU - Mattioli, Rodolfo
AU - Mazzei, Teresita
AU - Melotti, Rita Maria
AU - Menardo, Valentino
AU - Miotti, Danilo
AU - Moroso, Stefano
AU - Pascoletti, Gaetano
AU - De Santis, Stefano
AU - Orsetti, Remo
AU - Papa, Alfonso
AU - Ricci, Sergio
AU - Scelzi, Elvira
AU - Sofia, Michele
AU - Tonini, Giuseppe
AU - Valle, Alessandro
AU - Aielli, Federica
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Background: The aim of this study was to identify potential variables influencing the clinical presentation of breakthrough cancer pain (BTP). Methods: Cancer patients with a diagnosis of BTP were enrolled. Demographic and clinical characteristics, as well as background pain and BTP characteristics were collected. Multivariate analyses were conducted to assess the correlation between BTP characteristics and the variables examined. Results: Data of 4016 patients were analysed. Average daily number of BTP episodes was 2.4, mean intensity was 7.5, and a mean duration was 43.3 min. A short onset BTP was observed in 68.9% of patients. In 30.5% of patients BTP was predictable. There were 86.0% of participants who reported a marked interference of BTP with their daily activities. Furthermore, 86.8% of patients were receiving opioids for the management of BTP. The average time to meaningful pain relief was 16.5 min and 70.9% of patients were satisfied with their BTP medications. Age, head and neck cancer, Karnofsky, background pain intensity, predictable and fast onset BTP were independently associated with the number of BTP episodes. BTP pain intensity was independently associated with background pain intensity, fast onset BTP, and Karnofsky. Neuropathic pain mechanism was independently associated with unpredictable BTP. Variables independently associated with a longer duration of BTP were age, place of visit, cancer diagnosis, disease-oriented therapy, background pain intensity and mechanism, and unpredictable BTP. Age, Karnofsky, background pain intensity, fast onset, and long duration of BTP were independently associated with interference with daily activity. Conclusions: BTP has a variable presentation depending on interdependent relationships among its different characteristics.
AB - Background: The aim of this study was to identify potential variables influencing the clinical presentation of breakthrough cancer pain (BTP). Methods: Cancer patients with a diagnosis of BTP were enrolled. Demographic and clinical characteristics, as well as background pain and BTP characteristics were collected. Multivariate analyses were conducted to assess the correlation between BTP characteristics and the variables examined. Results: Data of 4016 patients were analysed. Average daily number of BTP episodes was 2.4, mean intensity was 7.5, and a mean duration was 43.3 min. A short onset BTP was observed in 68.9% of patients. In 30.5% of patients BTP was predictable. There were 86.0% of participants who reported a marked interference of BTP with their daily activities. Furthermore, 86.8% of patients were receiving opioids for the management of BTP. The average time to meaningful pain relief was 16.5 min and 70.9% of patients were satisfied with their BTP medications. Age, head and neck cancer, Karnofsky, background pain intensity, predictable and fast onset BTP were independently associated with the number of BTP episodes. BTP pain intensity was independently associated with background pain intensity, fast onset BTP, and Karnofsky. Neuropathic pain mechanism was independently associated with unpredictable BTP. Variables independently associated with a longer duration of BTP were age, place of visit, cancer diagnosis, disease-oriented therapy, background pain intensity and mechanism, and unpredictable BTP. Age, Karnofsky, background pain intensity, fast onset, and long duration of BTP were independently associated with interference with daily activity. Conclusions: BTP has a variable presentation depending on interdependent relationships among its different characteristics.
U2 - 10.3390/cancers10060175
DO - 10.3390/cancers10060175
M3 - Article
C2 - 29865170
VL - 10
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 6
ER -