Factors predicting response and graft-versus-host disease after donor lymphocyte infusions: A study on 593 infusions

A. M. Raiola, M. T. Van Lint, M. Valbonesi, T. Lamparelli, F. Gualandi, D. Occhini, S. Bregante, C. di Grazia, A. Dominietto, M. Soracco, C. Romagnani, F. Vassallo, M. Casini, B. Bruno, F. Frassoni, A. Bacigalupo

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, we analyze factors predicting graft-versus-host disease (GvHD) and response after donor lymphocyte infusions (DLI). A total of 100 patients received 593 DLI between June 1990 and December 2000 in a bulk dose (n = 14) or in escalating dose infusions (n = 86). Patients were analyzed after stratification for type of relapse: (1) molecular relapse (n = 6), (2) cytogenetic relapse (n = 20), (3) chronic phase of chronic myeloid leukemia (CML) or complete remission of other disease post chemotherapy (n = 24), (4) CML in accelerated/blastic phase (n = 14), (5) resistant disease not responding to chemotherapy (n = 36). The proportion of responders to DLI in these five groups was 100, 90, 75, 36 and 0% (P

Original languageEnglish
Pages (from-to)687-693
Number of pages7
JournalBone Marrow Transplantation
Volume31
Issue number8
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Donor lymphocyte infusion
  • GvHD
  • Relapse post-BMT
  • Response

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Factors predicting response and graft-versus-host disease after donor lymphocyte infusions: A study on 593 infusions'. Together they form a unique fingerprint.

Cite this