Factors predicting response to splenectomy in adult patients with idiopathic thrombocytopenic purpura

F. Radaelli, P. Faccini, M. Goldaniga, E. Guggiari, E. Pozzoli, A. T. Maiolo, A. Ciani, E. M. Pogliani

Research output: Contribution to journalArticle

Abstract

Background and Objectives. Splenectomy is the treatment of choice in the majority of patients affected by idiopathic thrombocytopenic purpura refractory to corticosteroid therapy, but it is not free from early and late complications. As the available literature does not seem to contain any precise indications concerning possible factors predicting the response to splenectomy, the aim of this retrospective study of 65 splenectomized patients was to attempt to identify potentially predictive clinical or laboratory parameters. Design and Methods. For the purposes of statistical analysis, the patients were divided into two groups: the first included those with a complete (platelets > 100x10 9/L) or partial response (platelets 50-100x10 9/L) to splenectomy; the second, the non-responders (platelets <50x10 9/L). The non-parametric tests were based on the Kruskal-Wallis method for independent samples, and the independent samples were compared using the Chi-square test according to Pearson. Results. Univariate analysis did not reveal any significant correlation between successful splenectomy and age, sex, platelet count at diagnosis, anti-platelets antibody positivity, the site of platelet sequestration, the time between diagnosis and surgery, or the response to high intravenous immunoglobulin doses. However, the probability of success greater in the patients with a complete or partial pre-operative response to steroid therapy (p

Original languageEnglish
Pages (from-to)1040-1044
Number of pages5
JournalHaematologica
Volume85
Issue number10
Publication statusPublished - 2000

Keywords

  • Factors predicting response
  • Idiopathic thrombocytopenic purpura
  • Splenectomy

ASJC Scopus subject areas

  • Hematology

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    Radaelli, F., Faccini, P., Goldaniga, M., Guggiari, E., Pozzoli, E., Maiolo, A. T., Ciani, A., & Pogliani, E. M. (2000). Factors predicting response to splenectomy in adult patients with idiopathic thrombocytopenic purpura. Haematologica, 85(10), 1040-1044.