Factors predicting transformation of asymptomatic IgM monoclonal gammopathy

Antonino Greco, Alessandra Tedeschi, Marzia Varettoni, Michele Nichelatti, Laura Paris, Francesca Ricci, Eleonora Vismara, Enrica Morra

Research output: Contribution to journalArticlepeer-review


We evaluated the risk of transformation of asymptomatic immunoglobulin (Ig) M monoclonal gammopathy (aIgM MG) into symptomatic lymphoproliferative disease in 287 patients all analyzed for bone marrow histopathology and immunophenotyping. This series included 201 patients with IgM MG of undetermined significance (IgM MGUS) and 86 with smoldering Waldenström's macroglobulinemia (sWM). After a median of 50 months (range, 12-322 months), 32 cases of aIgM-MG (11.1%) evolved into symptomatic malignant lymphoproliferative disease, as follows: symptomatic WM (n = 26), non-Hodgkin lymphoma (n = 6). The cumulative transformation percentage at 5 and 10 years was 8% and 19.5%, respectively. The parameters significantly correlated with evolution were, at univariate analysis, BM lymphoplasmacytic infiltration, high erythrocyte sedimentation rate, serum MC, serum IgM size, and serum IgA size. Among patients with aIgM-MG, those at high risk of evolution were patients with sWM, a distinct entity with serum IgM monoclonal protein ≥ 3 g/dL and/or ≥ 10% bone marrow lymphoplasmacytic infiltration.

Original languageEnglish
Pages (from-to)77-79
Number of pages3
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number1
Publication statusPublished - Feb 1 2011

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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