Abstract
Some tumors are known to produce colony-stimulating factors (CSF). In mice bearing s.c. Ehrlich tumor (ET) we observed that tumor growth is responsible for hemopoietic perturbations in which the increase of granulocytic-macrophagic precursors (CFU-C) in bone marrow and in the spleen represents a remarkable aspect. CFU-C in bone marrow from ET-bearing mice are more sensitive than CFU-C from normal mice to CSF from L-cells (LC-CM), mouse embryo fibroblasts (MEF-CM) and from the same tumor (ET-CM). Macrophages from normal and from ET-bearing mice exert the same effect on the proliferation of normal bone marrow CFU-C. Bone marrow CFU-C from ET-bearing mice show an increased sensitivity to the inhibitory factors produced by macrophages from ET-bearing mice.
| Original language | English |
|---|---|
| Pages (from-to) | 235-244 |
| Number of pages | 10 |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 102 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1982 |
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Keywords
- CFU-C
- CSF (colony-stimulating factor)
- Ehrlich tumor
- Inhibitory factors
- Macrophages
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Factors produced by macrophages and tumor cells : Influence on the granulocytic precursor cells (CFU-C) in normal and tumor-bearing mice. / Pessina, A.; Brambilla, P.; Villa, S.; Marocchi, A.; Mocarelli, P.
In: Journal of Cancer Research and Clinical Oncology, Vol. 102, No. 3, 01.1982, p. 235-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors produced by macrophages and tumor cells
T2 - Influence on the granulocytic precursor cells (CFU-C) in normal and tumor-bearing mice
AU - Pessina, A.
AU - Brambilla, P.
AU - Villa, S.
AU - Marocchi, A.
AU - Mocarelli, P.
PY - 1982/1
Y1 - 1982/1
N2 - Some tumors are known to produce colony-stimulating factors (CSF). In mice bearing s.c. Ehrlich tumor (ET) we observed that tumor growth is responsible for hemopoietic perturbations in which the increase of granulocytic-macrophagic precursors (CFU-C) in bone marrow and in the spleen represents a remarkable aspect. CFU-C in bone marrow from ET-bearing mice are more sensitive than CFU-C from normal mice to CSF from L-cells (LC-CM), mouse embryo fibroblasts (MEF-CM) and from the same tumor (ET-CM). Macrophages from normal and from ET-bearing mice exert the same effect on the proliferation of normal bone marrow CFU-C. Bone marrow CFU-C from ET-bearing mice show an increased sensitivity to the inhibitory factors produced by macrophages from ET-bearing mice.
AB - Some tumors are known to produce colony-stimulating factors (CSF). In mice bearing s.c. Ehrlich tumor (ET) we observed that tumor growth is responsible for hemopoietic perturbations in which the increase of granulocytic-macrophagic precursors (CFU-C) in bone marrow and in the spleen represents a remarkable aspect. CFU-C in bone marrow from ET-bearing mice are more sensitive than CFU-C from normal mice to CSF from L-cells (LC-CM), mouse embryo fibroblasts (MEF-CM) and from the same tumor (ET-CM). Macrophages from normal and from ET-bearing mice exert the same effect on the proliferation of normal bone marrow CFU-C. Bone marrow CFU-C from ET-bearing mice show an increased sensitivity to the inhibitory factors produced by macrophages from ET-bearing mice.
KW - CFU-C
KW - CSF (colony-stimulating factor)
KW - Ehrlich tumor
KW - Inhibitory factors
KW - Macrophages
UR - http://www.scopus.com/inward/record.url?scp=0020038063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020038063&partnerID=8YFLogxK
U2 - 10.1007/BF00411343
DO - 10.1007/BF00411343
M3 - Article
VL - 102
SP - 235
EP - 244
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 3
ER -