Abstract
Some tumors are known to produce colony-stimulating factors (CSF). In mice bearing s.c. Ehrlich tumor (ET) we observed that tumor growth is responsible for hemopoietic perturbations in which the increase of granulocytic-macrophagic precursors (CFU-C) in bone marrow and in the spleen represents a remarkable aspect. CFU-C in bone marrow from ET-bearing mice are more sensitive than CFU-C from normal mice to CSF from L-cells (LC-CM), mouse embryo fibroblasts (MEF-CM) and from the same tumor (ET-CM). Macrophages from normal and from ET-bearing mice exert the same effect on the proliferation of normal bone marrow CFU-C. Bone marrow CFU-C from ET-bearing mice show an increased sensitivity to the inhibitory factors produced by macrophages from ET-bearing mice.
Original language | English |
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Pages (from-to) | 235-244 |
Number of pages | 10 |
Journal | Journal of Cancer Research and Clinical Oncology |
Volume | 102 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jan 1982 |
Keywords
- CFU-C
- CSF (colony-stimulating factor)
- Ehrlich tumor
- Inhibitory factors
- Macrophages
ASJC Scopus subject areas
- Oncology
- Cancer Research