Factors produced by macrophages and tumor cells: Influence on the granulocytic precursor cells (CFU-C) in normal and tumor-bearing mice

A. Pessina, P. Brambilla, S. Villa, A. Marocchi, P. Mocarelli

Research output: Contribution to journalArticle

Abstract

Some tumors are known to produce colony-stimulating factors (CSF). In mice bearing s.c. Ehrlich tumor (ET) we observed that tumor growth is responsible for hemopoietic perturbations in which the increase of granulocytic-macrophagic precursors (CFU-C) in bone marrow and in the spleen represents a remarkable aspect. CFU-C in bone marrow from ET-bearing mice are more sensitive than CFU-C from normal mice to CSF from L-cells (LC-CM), mouse embryo fibroblasts (MEF-CM) and from the same tumor (ET-CM). Macrophages from normal and from ET-bearing mice exert the same effect on the proliferation of normal bone marrow CFU-C. Bone marrow CFU-C from ET-bearing mice show an increased sensitivity to the inhibitory factors produced by macrophages from ET-bearing mice.

Original languageEnglish
Pages (from-to)235-244
Number of pages10
JournalJournal of Cancer Research and Clinical Oncology
Volume102
Issue number3
DOIs
Publication statusPublished - Jan 1982

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Keywords

  • CFU-C
  • CSF (colony-stimulating factor)
  • Ehrlich tumor
  • Inhibitory factors
  • Macrophages

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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