Abstract
Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 239-249 |
| Number of pages | 11 |
| Journal | Cancer Treatment and Research |
| Volume | 40 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Factors regulating basement membrane invasion by tumor cells. / Thompson, E. W.; Reich, R.; Martin, G. R.; Albini, A.
In: Cancer Treatment and Research, Vol. 40, 1988, p. 239-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors regulating basement membrane invasion by tumor cells.
AU - Thompson, E. W.
AU - Reich, R.
AU - Martin, G. R.
AU - Albini, A.
PY - 1988
Y1 - 1988
N2 - Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells.
AB - Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells.
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M3 - Article
C2 - 2908653
AN - SCOPUS:0024154598
VL - 40
SP - 239
EP - 249
JO - Cancer Treatment and Research
JF - Cancer Treatment and Research
SN - 0927-3042
ER -