FAD synthesis and degradation in the nucleus create a local flavin cofactor pool

Teresa Anna Giancaspero, Giovanni Busco, Concetta Panebianco, Claudia Carmone, Angelica Miccolis, Grazia Maria Liuzzi, Matilde Colella, Maria Barile

Research output: Contribution to journalArticlepeer-review

Abstract

Background:FAD synthase is known to catalyze the biosynthesis of FAD in cytosol and mitochondria. Results:The existence of a nuclear FAD synthase and a FAD-hydrolyzing activity is demonstrated. Conclusion:A dynamic pool of FAD exists in the nucleus. Significance:Nuclear, mitochondrial, and cytosolic FAD synthase pools constitute a flavin network involved in the regulation of cellular metabolism and epigenetic events.

Original languageEnglish
Pages (from-to)29069-29080
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - Oct 4 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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