FAD synthesis and degradation in the nucleus create a local flavin cofactor pool

Teresa Anna Giancaspero; Giovanni Busco; Concetta Panebianco; Claudia Carmone; Angelica Miccolis; Grazia Maria Liuzzi; Matilde Colella; Maria Barile

doi:10.1074/jbc.M113.500066

FAD synthesis and degradation in the nucleus create a local flavin cofactor pool

Teresa Anna Giancaspero, Giovanni Busco, Concetta Panebianco, Claudia Carmone, Angelica Miccolis, Grazia Maria Liuzzi, Matilde Colella, Maria Barile

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article

Abstract

Background:FAD synthase is known to catalyze the biosynthesis of FAD in cytosol and mitochondria. Results:The existence of a nuclear FAD synthase and a FAD-hydrolyzing activity is demonstrated. Conclusion:A dynamic pool of FAD exists in the nucleus. Significance:Nuclear, mitochondrial, and cytosolic FAD synthase pools constitute a flavin network involved in the regulation of cellular metabolism and epigenetic events.

Original language	English
Pages (from-to)	29069-29080
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.500066
Publication status	Published - Oct 4 2013

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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Giancaspero, T. A., Busco, G., Panebianco, C., Carmone, C., Miccolis, A., Liuzzi, G. M., Colella, M., & Barile, M. (2013). FAD synthesis and degradation in the nucleus create a local flavin cofactor pool. Journal of Biological Chemistry, 288(40), 29069-29080. https://doi.org/10.1074/jbc.M113.500066

FAD synthesis and degradation in the nucleus create a local flavin cofactor pool. / Giancaspero, Teresa Anna; Busco, Giovanni; Panebianco, Concetta; Carmone, Claudia; Miccolis, Angelica; Liuzzi, Grazia Maria; Colella, Matilde; Barile, Maria.

In: Journal of Biological Chemistry, Vol. 288, No. 40, 04.10.2013, p. 29069-29080.

Research output: Contribution to journal › Article

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AU - Colella, Matilde

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