TY - JOUR
T1 - FAD synthesis and degradation in the nucleus create a local flavin cofactor pool
AU - Giancaspero, Teresa Anna
AU - Busco, Giovanni
AU - Panebianco, Concetta
AU - Carmone, Claudia
AU - Miccolis, Angelica
AU - Liuzzi, Grazia Maria
AU - Colella, Matilde
AU - Barile, Maria
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:FAD synthase is known to catalyze the biosynthesis of FAD in cytosol and mitochondria. Results:The existence of a nuclear FAD synthase and a FAD-hydrolyzing activity is demonstrated. Conclusion:A dynamic pool of FAD exists in the nucleus. Significance:Nuclear, mitochondrial, and cytosolic FAD synthase pools constitute a flavin network involved in the regulation of cellular metabolism and epigenetic events.
AB - Background:FAD synthase is known to catalyze the biosynthesis of FAD in cytosol and mitochondria. Results:The existence of a nuclear FAD synthase and a FAD-hydrolyzing activity is demonstrated. Conclusion:A dynamic pool of FAD exists in the nucleus. Significance:Nuclear, mitochondrial, and cytosolic FAD synthase pools constitute a flavin network involved in the regulation of cellular metabolism and epigenetic events.
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U2 - 10.1074/jbc.M113.500066
DO - 10.1074/jbc.M113.500066
M3 - Article
C2 - 23946482
AN - SCOPUS:84885109266
VL - 288
SP - 29069
EP - 29080
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 40
ER -