Abstract
Nine patients with lamivudine-resistant chronic hepatitis B infection who had been treated with adefovir 10 mg/day and had had a suboptimal response but did not have genotypic resistance to adefovir were treated with high-dose adefovir (20 mg/day). The response to the increased dose of adefovir was compared with the response in 15 patients with a suboptimal response who did not receive an increase in the dose of adefovir. The increase in the dose of adefovir did not lead to a significant reduction in hepatitis B DNA when compared with patients maintained on the standard dose. These data suggest that increasing the dose of adefovir in patients with a suboptimal response does not lead to an improved response.
Original language | English |
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Pages (from-to) | 922-924 |
Number of pages | 3 |
Journal | Journal of Viral Hepatitis |
Volume | 15 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- Adefovir dipivoxil
- Antiviral treatment
- HBV DNA
- Hepatitis B
- Lamivudine resistance
- Suboptimal response
ASJC Scopus subject areas
- Hepatology
- Infectious Diseases
- Virology