Failure of B Cells of Chronic Lymphocytic Leukemia in Presenting Soluble and Alloantigens

F. Dazzi, E. D'Andrea, G. Biasi, G. De Silvestro, G. Gaidano, M. Schena, T. Tison, F. Vianello, A. Girolami, F. Caligaris-Cappio

Research output: Contribution to journalArticle

Abstract

B-cell-type chronic lymphocytic leukemia (B-CLL) patients have immunological abnormalities of both B and T lymphocytes. Since T cell defects might depend upon a defective accessory function of neoplastic B lymphocytes, we analyzed the ability of peripheral blood B cells of seven B-CLL patients to stimulate allogenic normal T cells in mixed lymphocyte reaction (MLR) and to present tetanus toxoid (TT) to autologous T cells. In both systems, neoplastic B lymphocytes show a defective antigen-presenting function, which is more evident with disease progression. Such a defect cannot be ascribed to a decreased MHC class II molecule expression nor to an abnormal IL-1β production, but it can be partially accounted for by a low B7 expression. Pretreatment of neoplastic B cells with interleukin-4 (IL-4) restores primary MLR, but has little effect on the response to TT. The effect of IL-4 is not mediated by quantitative modifications of class II and B7 molecule expression or of IL-1β production.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalClinical Immunology and Immunopathology
Volume75
Issue number1
DOIs
Publication statusPublished - Apr 1995

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Immunology

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    Dazzi, F., D'Andrea, E., Biasi, G., De Silvestro, G., Gaidano, G., Schena, M., Tison, T., Vianello, F., Girolami, A., & Caligaris-Cappio, F. (1995). Failure of B Cells of Chronic Lymphocytic Leukemia in Presenting Soluble and Alloantigens. Clinical Immunology and Immunopathology, 75(1), 26-32. https://doi.org/10.1006/clin.1995.1048