Failure of chronic haloperidol to affect prolactin secretion due to acute haloperidol administration

E. A. Parati, M. Parenti, V. Locatelli, A. Penalva, C. Tanringa, E. E. Müller

Research output: Contribution to journalArticle

Abstract

Withdrawal from chronic haloperidol exposure was associated to unaltered circulating levels of prolactin (PRL), decreased 3H-spiperone binding sites in the anterior pituitary and increased 3H-spiperone binding sites in the striatum of male rats. Haloperidol (0.1 mg/kg ip) induced similar rises in plasma PRL in haloperidol-or saline-treated rats and the dose of 0.01 mg/kg was ineffective in both groups. These findings illustrate the poor relatedness existing at the pituitary D2 receptor between biochemical and functional indices.

Original languageEnglish
Pages (from-to)407-415
Number of pages9
JournalPharmacological Research Communications
Volume17
Issue number5
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pharmacology

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