Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease

Andrea Taddio, Alberto Tommasini, Erica Valencic, Ettore Biagi, Giuliana Decorti, Sara De Iudicibus, Eva Cuzzoni, Giuseppe Gaipa, Raffaela Badolato, Alberto Prandini, Andrea Biondi, Alessandro Ventura

Research output: Contribution to journalArticlepeer-review

Abstract

Mesenchymal stem cells (MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro. It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders. We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells. Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation. The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders.

Original languageEnglish
Pages (from-to)4379-4384
Number of pages6
JournalWorld Journal of Gastroenterology
Volume21
Issue number14
DOIs
Publication statusPublished - Apr 14 2015

Keywords

  • Autoimmune disease
  • Crohn's disease
  • Immune regulation
  • Interferon-γ
  • Mesenchymal stem cells
  • Pretreatment

ASJC Scopus subject areas

  • Gastroenterology

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