Failure of primary breast cancer neoangiogenesis to predict pattern of distant metastasis

A. Paradiso, G. Ranieri, N. Silvestris, G. Naccarato, G. Bevilacqua, A. Mangia, B. Leone, C. Vallejo, G. Simone, F. Schittulli, M. De Lena

Research output: Contribution to journalArticlepeer-review


In the present study, the primary tumor neoangiogenesis characteristics of 81 stage IV previously untreated breast cancers with synchronous metastasis to different distant sites (10 patients with soft tissue metastases, 31 with bone metastases, and 40 with visceral metastases) were analyzed. The primary intratumor microvessel density was assessed by immunohistochemical assay on paraffin-embedded primary tumor samples, using a monoclonal anti-CD34 antibody. The mean primary intratumor microvessel density (at 400× fields) was 78±39 (SD) microvessels per field. The microvessel density was not significantly related to the main clinical/pathological features of the tumor (age, cytohistological grade, DNA ploidy, diameter, and receptor status). The percentage of tumor cases with high primary intratumor microvessel density (cut-off median value of the series 73±39 microvessels/field) did not significantly differ in patients with bone, soft tissue, or visceral metastatic disease. Analysis of clinical outcome showed a significantly shorter time to progression and overall survival for patients with visceral metastases (P

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalClinical and Experimental Medicine
Issue number3
Publication statusPublished - 2001


  • Breast cancer
  • Neoangiogenesis
  • Site-specific metastasis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry


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