Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients

P. Pronzato, M. Landucci, F. Vaira, A. Vigani, G. Bertelli

Research output: Contribution to journalArticle

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Abstract

Fifteen patients with advanced non-small cell lung cancer, already treated with first-line chemotherapy entered a protocol of palliative second-line treatment with the hemysynthetic vinca alkaloid vinorelbine (25 mg/sm weekly for two months). No patient obtained an objective response and the trial was stopped. Toxicity was not as mild as expected, with one treatment-related death due to leukopenia. It is concluded that single-agent vinorelbine although effective as front-line chemotherapy for non-small cell lung cancer patients is probably not suitable for palliative treatment of pretreated patients.

Original languageEnglish
Pages (from-to)1413-1415
Number of pages3
JournalAnticancer Research
Volume14
Issue number3 B
Publication statusPublished - 1994

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Non-Small Cell Lung Carcinoma
Vinca Alkaloids
Drug Therapy
Leukopenia
Palliative Care
vinorelbine
Therapeutics

Keywords

  • Non-small cell lung cancer
  • Second-line chemotherapy
  • Vinorelbine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pronzato, P., Landucci, M., Vaira, F., Vigani, A., & Bertelli, G. (1994). Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients. Anticancer Research, 14(3 B), 1413-1415.

Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients. / Pronzato, P.; Landucci, M.; Vaira, F.; Vigani, A.; Bertelli, G.

In: Anticancer Research, Vol. 14, No. 3 B, 1994, p. 1413-1415.

Research output: Contribution to journalArticle

Pronzato, P, Landucci, M, Vaira, F, Vigani, A & Bertelli, G 1994, 'Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients', Anticancer Research, vol. 14, no. 3 B, pp. 1413-1415.
Pronzato, P. ; Landucci, M. ; Vaira, F. ; Vigani, A. ; Bertelli, G. / Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients. In: Anticancer Research. 1994 ; Vol. 14, No. 3 B. pp. 1413-1415.
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