Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients

P. Pronzato, M. Landucci, F. Vaira, A. Vigani, G. Bertelli

Research output: Contribution to journalArticle

Abstract

Fifteen patients with advanced non-small cell lung cancer, already treated with first-line chemotherapy entered a protocol of palliative second-line treatment with the hemysynthetic vinca alkaloid vinorelbine (25 mg/sm weekly for two months). No patient obtained an objective response and the trial was stopped. Toxicity was not as mild as expected, with one treatment-related death due to leukopenia. It is concluded that single-agent vinorelbine although effective as front-line chemotherapy for non-small cell lung cancer patients is probably not suitable for palliative treatment of pretreated patients.

Original languageEnglish
Pages (from-to)1413-1415
Number of pages3
JournalAnticancer Research
Volume14
Issue number3 B
Publication statusPublished - 1994

Keywords

  • Non-small cell lung cancer
  • Second-line chemotherapy
  • Vinorelbine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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