Failure of warfarin to affect the tissue factor activity and the metastatic potential of murine fibrosarcoma cells

R. Lorenzet, B. Bottazzi, D. Locati, M. Colucci, A. Mantovani, N. Semeraro, M. B. Donati

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Vitamin K deficiency, either dietary or pharmacologically induced by warfarin, was unable to affect the metastatic capacity of cells from a benzopyrene-induced fibrosarcoma in C57BL/6J mice. The same cells had a procoagulant activity, of tissue thromboplastin type, which was also completely unaffected by vitamin K antagonism or deficiency. In another murine model of spontaneous metastasis we previously suggested that depression of a particular procoagulant such as a direct factor X activator might contribute to the antimetastatic activity of warfarin. The failure of vitamin K deficiency to affect both the procoagulant and the metastatic capacity of the model reported here offers strong negative support to the same concept.

Original languageEnglish
Pages (from-to)263-265
Number of pages3
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number2
Publication statusPublished - 1985


ASJC Scopus subject areas

  • Oncology

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