TY - JOUR
T1 - Failure of warfarin to affect the tissue factor activity and the metastatic potential of murine fibrosarcoma cells
AU - Lorenzet, R.
AU - Bottazzi, B.
AU - Locati, D.
AU - Colucci, M.
AU - Mantovani, A.
AU - Semeraro, N.
AU - Donati, M. B.
PY - 1985
Y1 - 1985
N2 - Vitamin K deficiency, either dietary or pharmacologically induced by warfarin, was unable to affect the metastatic capacity of cells from a benzopyrene-induced fibrosarcoma in C57BL/6J mice. The same cells had a procoagulant activity, of tissue thromboplastin type, which was also completely unaffected by vitamin K antagonism or deficiency. In another murine model of spontaneous metastasis we previously suggested that depression of a particular procoagulant such as a direct factor X activator might contribute to the antimetastatic activity of warfarin. The failure of vitamin K deficiency to affect both the procoagulant and the metastatic capacity of the model reported here offers strong negative support to the same concept.
AB - Vitamin K deficiency, either dietary or pharmacologically induced by warfarin, was unable to affect the metastatic capacity of cells from a benzopyrene-induced fibrosarcoma in C57BL/6J mice. The same cells had a procoagulant activity, of tissue thromboplastin type, which was also completely unaffected by vitamin K antagonism or deficiency. In another murine model of spontaneous metastasis we previously suggested that depression of a particular procoagulant such as a direct factor X activator might contribute to the antimetastatic activity of warfarin. The failure of vitamin K deficiency to affect both the procoagulant and the metastatic capacity of the model reported here offers strong negative support to the same concept.
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U2 - 10.1016/0277-5379(85)90182-8
DO - 10.1016/0277-5379(85)90182-8
M3 - Article
VL - 21
SP - 263
EP - 265
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 2
ER -