Failure of warfarin to affect the tissue factor activity and the metastastic potential of murine fibrosarcoma cells

R. Lorenzet, B. Bottazzi, D. Locati, M. Colucci, A. Mantovani, N. Semeraro, M. B. Donati

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Vitamin K deficiency, either dietary or pharmacologically induced by warfarin, was unable to affect the metastatic capacity of cells from a benzopyrene-induced fibrosarcoma in C57BL/6J mice. The same cells had a procoagulant activity, of tissue thromboplastin type, which was also completely unaffected by vitamin K antagonism or deficiency. In another murine model of spontaneous metastasis we previously suggested that depression of a particular procoagulant such as a direct factor X activator might contribute to the antimetastatic activity of warfarin. The failure of vitamin K deficiency to affect both the procoagulant and the metastatic capacity of the model reported here offers strong negative support to the same concept.

Original languageEnglish
Pages (from-to)263-265
Number of pages3
JournalEuropean Journal of Cancer and Clinical Oncology
Volume21
Issue number2
DOIs
Publication statusPublished - 1985

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Vitamin K Deficiency
Fibrosarcoma
cancer procoagulant
Thromboplastin
Warfarin
Benzopyrenes
Avitaminosis
Vitamin K
Inbred C57BL Mouse
Neoplasm Metastasis

ASJC Scopus subject areas

  • Oncology

Cite this

Failure of warfarin to affect the tissue factor activity and the metastastic potential of murine fibrosarcoma cells. / Lorenzet, R.; Bottazzi, B.; Locati, D.; Colucci, M.; Mantovani, A.; Semeraro, N.; Donati, M. B.

In: European Journal of Cancer and Clinical Oncology, Vol. 21, No. 2, 1985, p. 263-265.

Research output: Contribution to journalArticle

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AU - Semeraro, N.

AU - Donati, M. B.

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