TY - JOUR
T1 - Failure to eradicate HIV despite fully successful HAART initiated in the first days of life
AU - Viganò, Alessandra
AU - Trabattoni, Daria
AU - Schneider, Laura
AU - Ottaviani, Francesco
AU - Aliffi, Antonia
AU - Longhi, Erika
AU - Rusconi, Stefano
AU - Clerici, Mario
PY - 2006/3
Y1 - 2006/3
N2 - Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.
AB - Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.
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U2 - 10.1016/j.jpeds.2005.11.037
DO - 10.1016/j.jpeds.2005.11.037
M3 - Article
C2 - 16615974
AN - SCOPUS:33646005464
VL - 148
SP - 389
EP - 391
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -