Failure to eradicate HIV despite fully successful HAART initiated in the first days of life

Alessandra Viganò; Daria Trabattoni; Laura Schneider; Francesco Ottaviani; Antonia Aliffi; Erika Longhi; Stefano Rusconi; Mario Clerici

doi:10.1016/j.jpeds.2005.11.037

Failure to eradicate HIV despite fully successful HAART initiated in the first days of life

Alessandra Viganò, Daria Trabattoni, Laura Schneider, Francesco Ottaviani, Antonia Aliffi, Erika Longhi, Stefano Rusconi, Mario Clerici

Research output: Contribution to journal › Article

Abstract

Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.

Original language	English
Pages (from-to)	389-391
Number of pages	3
Journal	Journal of Pediatrics
Volume	148
Issue number	3
DOIs	https://doi.org/10.1016/j.jpeds.2005.11.037
Publication status	Published - Mar 2006

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ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

Viganò, A., Trabattoni, D., Schneider, L., Ottaviani, F., Aliffi, A., Longhi, E., Rusconi, S., & Clerici, M. (2006). Failure to eradicate HIV despite fully successful HAART initiated in the first days of life. Journal of Pediatrics, 148(3), 389-391. https://doi.org/10.1016/j.jpeds.2005.11.037

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AU - Clerici, Mario

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10.1016/j.jpeds.2005.11.037