Failure to eradicate HIV despite fully successful HAART initiated in the first days of life

Alessandra Viganò, Daria Trabattoni, Laura Schneider, Francesco Ottaviani, Antonia Aliffi, Erika Longhi, Stefano Rusconi, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

Highly active antiretroviral therapy (HAART) started shortly after birth resulted in reversion of human immunodeficiency virus (HIV) plasma viremia, proviral DNA in PBMC, viral culture, and serum HIV antibodies to negative. Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalJournal of Pediatrics
Volume148
Issue number3
DOIs
Publication statusPublished - Mar 2006

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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