Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients

Francesco Lescai, Chiara Pirazzini, Giuseppe D'Agostino, Aurelia Santoro, Roberta Ghidoni, Luisa Benussi, Daniela Galimberti, Esposito Federica, Francesca Marchegiani, Maurizio Cardelli, Fabiola Olivieri, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Fabrizio Tagliavini, Diego Albani, Filippo Martinelli Boneschi, Giuliano Binetti, Gianluigi Forloni, Pierluigi QuadriElio Scarpini, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalJournal of Alzheimer's Disease
Volume21
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

Italy
Single Nucleotide Polymorphism
Alzheimer Disease
Logistic Models
Alleles
Genome
Population
Genes
Alzheimer disease type 1

Keywords

  • Alzheimer's disease
  • APOE
  • genetics
  • replication

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

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title = "Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients",
abstract = "A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.",
keywords = "Alzheimer's disease, APOE, genetics, replication",
author = "Francesco Lescai and Chiara Pirazzini and Giuseppe D'Agostino and Aurelia Santoro and Roberta Ghidoni and Luisa Benussi and Daniela Galimberti and Esposito Federica and Francesca Marchegiani and Maurizio Cardelli and Fabiola Olivieri and Benedetta Nacmias and Sandro Sorbi and Silvia Bagnoli and Fabrizio Tagliavini and Diego Albani and Boneschi, {Filippo Martinelli} and Giuliano Binetti and Gianluigi Forloni and Pierluigi Quadri and Elio Scarpini and Claudio Franceschi",
year = "2010",
doi = "10.3233/JAD-2010-091516",
language = "English",
volume = "21",
pages = "385--388",
journal = "Journal of Alzheimer's Disease",
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TY - JOUR

T1 - Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients

AU - Lescai, Francesco

AU - Pirazzini, Chiara

AU - D'Agostino, Giuseppe

AU - Santoro, Aurelia

AU - Ghidoni, Roberta

AU - Benussi, Luisa

AU - Galimberti, Daniela

AU - Federica, Esposito

AU - Marchegiani, Francesca

AU - Cardelli, Maurizio

AU - Olivieri, Fabiola

AU - Nacmias, Benedetta

AU - Sorbi, Sandro

AU - Bagnoli, Silvia

AU - Tagliavini, Fabrizio

AU - Albani, Diego

AU - Boneschi, Filippo Martinelli

AU - Binetti, Giuliano

AU - Forloni, Gianluigi

AU - Quadri, Pierluigi

AU - Scarpini, Elio

AU - Franceschi, Claudio

PY - 2010

Y1 - 2010

N2 - A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.

AB - A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.

KW - Alzheimer's disease

KW - APOE

KW - genetics

KW - replication

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