Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients

Francesco Lescai, Chiara Pirazzini, Giuseppe D'Agostino, Aurelia Santoro, Roberta Ghidoni, Luisa Benussi, Daniela Galimberti, Esposito Federica, Francesca Marchegiani, Maurizio Cardelli, Fabiola Olivieri, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Fabrizio Tagliavini, Diego Albani, Filippo Martinelli Boneschi, Giuliano Binetti, Gianluigi Forloni, Pierluigi QuadriElio Scarpini, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalJournal of Alzheimer's Disease
Volume21
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • Alzheimer's disease
  • APOE
  • genetics
  • replication

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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