Falls, fractures and bone density in Parkinson's disease - a cross-sectional study

Cristina Tassorelli, Mariangela Berlangieri, Simona Buscone, Monica Bolla, Roberto De Icco, Alessio Baricich, Claudio Pacchetti, Carlo Cisari, Giorgio Sandrini

Research output: Contribution to journalArticle

Abstract

AIM: Evidence suggests that falls and associated bone fractures are more frequent in patients suffering from Parkinson's disease (PD) than in the general population. In this cross-sectional study we evaluated the clinical and biochemical characteristics that are associated to falls, fractures and bone health in a population of PD subjects.

MATERIALS AND METHODS: Forty-two consecutive subjects suffering from idiopathic PD (mild-to-moderate severity) with/without falls in the previous year were included. They were characterized as regards functional independence, balance, fear of falling, bone density (ultrasound densitometry) and plasma levels of vitamin D. Twenty-one age- and sex-matched healthy subjects were evaluated as controls.

RESULTS: We detected a greater degree of osteoporosis in PD subjects as compared to controls, more pronounced in males than in females (Z-score: M -3.8 ± 1.6, F -2.28 ± 0.92, p = 0.0006). A positive correlation was found between independence levels and bone density or vitamin D levels. Twenty seven patients (64%) reported falls in the previous year. These were associated to post-traumatic fractures in 16 subjects (59% of fallers). Women fell more than men (fallers: 20 F/7 M; non fallers: 4 F/11 M, χ² test p = 0.02), although the occurrence of post-traumatic fractures among fallers did not differ between sexes (F 11/9, M 5/2, χ² test p > 0.05). Fallers with post-traumatic fractures showed higher degrees of motor impairment.

CONCLUSIONS: These findings confirm that falls and osteoporosis represent major health issues in PD, already in the middle stages of disease.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalInternational Journal of Neuroscience
Volume127
Issue number4
DOIs
Publication statusPublished - Apr 2017

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Densitometry
Bone Fractures
Parkinson Disease
Cross-Sectional Studies
Vitamin D
Osteoporosis
Accidental Falls
Bone and Bones
Health
Population
Fear
Healthy Volunteers

Keywords

  • Accidental Falls
  • Aged
  • Aged, 80 and over
  • Bone Density
  • Cross-Sectional Studies
  • Densitometry
  • Fear
  • Female
  • Fractures, Bone
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease
  • Postural Balance
  • Sensation Disorders
  • Severity of Illness Index
  • Sex Factors
  • Ultrasonography
  • Vitamin D
  • Journal Article

Cite this

Falls, fractures and bone density in Parkinson's disease - a cross-sectional study. / Tassorelli, Cristina; Berlangieri, Mariangela; Buscone, Simona; Bolla, Monica; De Icco, Roberto; Baricich, Alessio; Pacchetti, Claudio; Cisari, Carlo; Sandrini, Giorgio.

In: International Journal of Neuroscience, Vol. 127, No. 4, 04.2017, p. 299-304.

Research output: Contribution to journalArticle

Tassorelli, Cristina ; Berlangieri, Mariangela ; Buscone, Simona ; Bolla, Monica ; De Icco, Roberto ; Baricich, Alessio ; Pacchetti, Claudio ; Cisari, Carlo ; Sandrini, Giorgio. / Falls, fractures and bone density in Parkinson's disease - a cross-sectional study. In: International Journal of Neuroscience. 2017 ; Vol. 127, No. 4. pp. 299-304.
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abstract = "AIM: Evidence suggests that falls and associated bone fractures are more frequent in patients suffering from Parkinson's disease (PD) than in the general population. In this cross-sectional study we evaluated the clinical and biochemical characteristics that are associated to falls, fractures and bone health in a population of PD subjects.MATERIALS AND METHODS: Forty-two consecutive subjects suffering from idiopathic PD (mild-to-moderate severity) with/without falls in the previous year were included. They were characterized as regards functional independence, balance, fear of falling, bone density (ultrasound densitometry) and plasma levels of vitamin D. Twenty-one age- and sex-matched healthy subjects were evaluated as controls.RESULTS: We detected a greater degree of osteoporosis in PD subjects as compared to controls, more pronounced in males than in females (Z-score: M -3.8 ± 1.6, F -2.28 ± 0.92, p = 0.0006). A positive correlation was found between independence levels and bone density or vitamin D levels. Twenty seven patients (64{\%}) reported falls in the previous year. These were associated to post-traumatic fractures in 16 subjects (59{\%} of fallers). Women fell more than men (fallers: 20 F/7 M; non fallers: 4 F/11 M, χ² test p = 0.02), although the occurrence of post-traumatic fractures among fallers did not differ between sexes (F 11/9, M 5/2, χ² test p > 0.05). Fallers with post-traumatic fractures showed higher degrees of motor impairment.CONCLUSIONS: These findings confirm that falls and osteoporosis represent major health issues in PD, already in the middle stages of disease.",
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T1 - Falls, fractures and bone density in Parkinson's disease - a cross-sectional study

AU - Tassorelli, Cristina

AU - Berlangieri, Mariangela

AU - Buscone, Simona

AU - Bolla, Monica

AU - De Icco, Roberto

AU - Baricich, Alessio

AU - Pacchetti, Claudio

AU - Cisari, Carlo

AU - Sandrini, Giorgio

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N2 - AIM: Evidence suggests that falls and associated bone fractures are more frequent in patients suffering from Parkinson's disease (PD) than in the general population. In this cross-sectional study we evaluated the clinical and biochemical characteristics that are associated to falls, fractures and bone health in a population of PD subjects.MATERIALS AND METHODS: Forty-two consecutive subjects suffering from idiopathic PD (mild-to-moderate severity) with/without falls in the previous year were included. They were characterized as regards functional independence, balance, fear of falling, bone density (ultrasound densitometry) and plasma levels of vitamin D. Twenty-one age- and sex-matched healthy subjects were evaluated as controls.RESULTS: We detected a greater degree of osteoporosis in PD subjects as compared to controls, more pronounced in males than in females (Z-score: M -3.8 ± 1.6, F -2.28 ± 0.92, p = 0.0006). A positive correlation was found between independence levels and bone density or vitamin D levels. Twenty seven patients (64%) reported falls in the previous year. These were associated to post-traumatic fractures in 16 subjects (59% of fallers). Women fell more than men (fallers: 20 F/7 M; non fallers: 4 F/11 M, χ² test p = 0.02), although the occurrence of post-traumatic fractures among fallers did not differ between sexes (F 11/9, M 5/2, χ² test p > 0.05). Fallers with post-traumatic fractures showed higher degrees of motor impairment.CONCLUSIONS: These findings confirm that falls and osteoporosis represent major health issues in PD, already in the middle stages of disease.

AB - AIM: Evidence suggests that falls and associated bone fractures are more frequent in patients suffering from Parkinson's disease (PD) than in the general population. In this cross-sectional study we evaluated the clinical and biochemical characteristics that are associated to falls, fractures and bone health in a population of PD subjects.MATERIALS AND METHODS: Forty-two consecutive subjects suffering from idiopathic PD (mild-to-moderate severity) with/without falls in the previous year were included. They were characterized as regards functional independence, balance, fear of falling, bone density (ultrasound densitometry) and plasma levels of vitamin D. Twenty-one age- and sex-matched healthy subjects were evaluated as controls.RESULTS: We detected a greater degree of osteoporosis in PD subjects as compared to controls, more pronounced in males than in females (Z-score: M -3.8 ± 1.6, F -2.28 ± 0.92, p = 0.0006). A positive correlation was found between independence levels and bone density or vitamin D levels. Twenty seven patients (64%) reported falls in the previous year. These were associated to post-traumatic fractures in 16 subjects (59% of fallers). Women fell more than men (fallers: 20 F/7 M; non fallers: 4 F/11 M, χ² test p = 0.02), although the occurrence of post-traumatic fractures among fallers did not differ between sexes (F 11/9, M 5/2, χ² test p > 0.05). Fallers with post-traumatic fractures showed higher degrees of motor impairment.CONCLUSIONS: These findings confirm that falls and osteoporosis represent major health issues in PD, already in the middle stages of disease.

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KW - Fear

KW - Female

KW - Fractures, Bone

KW - Humans

KW - Male

KW - Middle Aged

KW - Parkinson Disease

KW - Postural Balance

KW - Sensation Disorders

KW - Severity of Illness Index

KW - Sex Factors

KW - Ultrasonography

KW - Vitamin D

KW - Journal Article

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DO - 10.1080/00207454.2016.1206897

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VL - 127

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JO - International Journal of Neuroscience

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