Abstract
AIM: Evidence suggests that falls and associated bone fractures are more frequent in patients suffering from Parkinson's disease (PD) than in the general population. In this cross-sectional study we evaluated the clinical and biochemical characteristics that are associated to falls, fractures and bone health in a population of PD subjects.
MATERIALS AND METHODS: Forty-two consecutive subjects suffering from idiopathic PD (mild-to-moderate severity) with/without falls in the previous year were included. They were characterized as regards functional independence, balance, fear of falling, bone density (ultrasound densitometry) and plasma levels of vitamin D. Twenty-one age- and sex-matched healthy subjects were evaluated as controls.
RESULTS: We detected a greater degree of osteoporosis in PD subjects as compared to controls, more pronounced in males than in females (Z-score: M -3.8 ± 1.6, F -2.28 ± 0.92, p = 0.0006). A positive correlation was found between independence levels and bone density or vitamin D levels. Twenty seven patients (64%) reported falls in the previous year. These were associated to post-traumatic fractures in 16 subjects (59% of fallers). Women fell more than men (fallers: 20 F/7 M; non fallers: 4 F/11 M, χ² test p = 0.02), although the occurrence of post-traumatic fractures among fallers did not differ between sexes (F 11/9, M 5/2, χ² test p > 0.05). Fallers with post-traumatic fractures showed higher degrees of motor impairment.
CONCLUSIONS: These findings confirm that falls and osteoporosis represent major health issues in PD, already in the middle stages of disease.
| Original language | English |
|---|---|
| Pages (from-to) | 299-304 |
| Number of pages | 6 |
| Journal | International Journal of Neuroscience |
| Volume | 127 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2017 |
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Keywords
- Accidental Falls
- Aged
- Aged, 80 and over
- Bone Density
- Cross-Sectional Studies
- Densitometry
- Fear
- Female
- Fractures, Bone
- Humans
- Male
- Middle Aged
- Parkinson Disease
- Postural Balance
- Sensation Disorders
- Severity of Illness Index
- Sex Factors
- Ultrasonography
- Vitamin D
- Journal Article
Cite this
Falls, fractures and bone density in Parkinson's disease - a cross-sectional study. / Tassorelli, Cristina; Berlangieri, Mariangela; Buscone, Simona; Bolla, Monica; De Icco, Roberto; Baricich, Alessio; Pacchetti, Claudio; Cisari, Carlo; Sandrini, Giorgio.
In: International Journal of Neuroscience, Vol. 127, No. 4, 04.2017, p. 299-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Falls, fractures and bone density in Parkinson's disease - a cross-sectional study
AU - Tassorelli, Cristina
AU - Berlangieri, Mariangela
AU - Buscone, Simona
AU - Bolla, Monica
AU - De Icco, Roberto
AU - Baricich, Alessio
AU - Pacchetti, Claudio
AU - Cisari, Carlo
AU - Sandrini, Giorgio
PY - 2017/4
Y1 - 2017/4
N2 - AIM: Evidence suggests that falls and associated bone fractures are more frequent in patients suffering from Parkinson's disease (PD) than in the general population. In this cross-sectional study we evaluated the clinical and biochemical characteristics that are associated to falls, fractures and bone health in a population of PD subjects.MATERIALS AND METHODS: Forty-two consecutive subjects suffering from idiopathic PD (mild-to-moderate severity) with/without falls in the previous year were included. They were characterized as regards functional independence, balance, fear of falling, bone density (ultrasound densitometry) and plasma levels of vitamin D. Twenty-one age- and sex-matched healthy subjects were evaluated as controls.RESULTS: We detected a greater degree of osteoporosis in PD subjects as compared to controls, more pronounced in males than in females (Z-score: M -3.8 ± 1.6, F -2.28 ± 0.92, p = 0.0006). A positive correlation was found between independence levels and bone density or vitamin D levels. Twenty seven patients (64%) reported falls in the previous year. These were associated to post-traumatic fractures in 16 subjects (59% of fallers). Women fell more than men (fallers: 20 F/7 M; non fallers: 4 F/11 M, χ² test p = 0.02), although the occurrence of post-traumatic fractures among fallers did not differ between sexes (F 11/9, M 5/2, χ² test p > 0.05). Fallers with post-traumatic fractures showed higher degrees of motor impairment.CONCLUSIONS: These findings confirm that falls and osteoporosis represent major health issues in PD, already in the middle stages of disease.
AB - AIM: Evidence suggests that falls and associated bone fractures are more frequent in patients suffering from Parkinson's disease (PD) than in the general population. In this cross-sectional study we evaluated the clinical and biochemical characteristics that are associated to falls, fractures and bone health in a population of PD subjects.MATERIALS AND METHODS: Forty-two consecutive subjects suffering from idiopathic PD (mild-to-moderate severity) with/without falls in the previous year were included. They were characterized as regards functional independence, balance, fear of falling, bone density (ultrasound densitometry) and plasma levels of vitamin D. Twenty-one age- and sex-matched healthy subjects were evaluated as controls.RESULTS: We detected a greater degree of osteoporosis in PD subjects as compared to controls, more pronounced in males than in females (Z-score: M -3.8 ± 1.6, F -2.28 ± 0.92, p = 0.0006). A positive correlation was found between independence levels and bone density or vitamin D levels. Twenty seven patients (64%) reported falls in the previous year. These were associated to post-traumatic fractures in 16 subjects (59% of fallers). Women fell more than men (fallers: 20 F/7 M; non fallers: 4 F/11 M, χ² test p = 0.02), although the occurrence of post-traumatic fractures among fallers did not differ between sexes (F 11/9, M 5/2, χ² test p > 0.05). Fallers with post-traumatic fractures showed higher degrees of motor impairment.CONCLUSIONS: These findings confirm that falls and osteoporosis represent major health issues in PD, already in the middle stages of disease.
KW - Accidental Falls
KW - Aged
KW - Aged, 80 and over
KW - Bone Density
KW - Cross-Sectional Studies
KW - Densitometry
KW - Fear
KW - Female
KW - Fractures, Bone
KW - Humans
KW - Male
KW - Middle Aged
KW - Parkinson Disease
KW - Postural Balance
KW - Sensation Disorders
KW - Severity of Illness Index
KW - Sex Factors
KW - Ultrasonography
KW - Vitamin D
KW - Journal Article
U2 - 10.1080/00207454.2016.1206897
DO - 10.1080/00207454.2016.1206897
M3 - Article
C2 - 27356592
VL - 127
SP - 299
EP - 304
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
SN - 0020-7454
IS - 4
ER -