False-negative sentinel node in patients with vulvar cancer: A case study

Francesco Raspagliesi, A. Ditto, R. Fontanelli, M. Maccauro, M. L. Carcangiu, F. Parazzini, E. Bombardieri

Research output: Contribution to journalArticlepeer-review


Evidence from recent studies indicates that the technique of sentinel node biopsy might be a useful solution for detecting lymph node status for primary vulvar cancer without having to perform radical inguinal lymphadenectomy. The patient in this report underwent sentinel node biopsy, then bilateral inguino-femoral node dissection, and, lastly, radical vulvectomy. The histologic analysis showed a well differentiated squamous cell carcinoma with metastases in one right inguinal node and one left inguinal node and a false-negative right sentinel node. Technically the biopsy of groin sentinel nodes should be quite easy to perform. The use of preoperative lymphoscintigraphy and the intraoperative use of the gamma probe combined with blue dye helps considerably in identifying lymphatic drainage and the sentinel node for vulvar cancer. Further results are needed to confirm the value of sentinel node dissection in the treatment of early stage vulvar cancer.

Original languageEnglish
Pages (from-to)361-363
Number of pages3
JournalInternational Journal of Gynecological Cancer
Issue number3
Publication statusPublished - May 2003


  • Lymphadenectomy
  • Lymphatic mapping
  • Lymphoscintigraphy
  • Sentinel lymph node biopsy
  • Vulvar cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Cancer Research


Dive into the research topics of 'False-negative sentinel node in patients with vulvar cancer: A case study'. Together they form a unique fingerprint.

Cite this