False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers

Vincenzo Triggiani, Vito Angelo Giagulli, Michele Iovino, Giovanni de Pergola, Brunella Licchelli, Antonio Varraso, Franca Dicembrino, Guido Valle, Edoardo Guastamacchia

Research output: Contribution to journalArticle

Abstract

131Iodine is used both to ablate any residual thyroid tissue or metastatic disease and to obtain whole-body diagnostic images after total thyroidectomy for differentiated thyroid cancer (DTC). Even though whole-body scan is highly accurate in showing thyroid residues as well as metastases of DTC, false positive results can be found, possibly leading to diagnostic errors and unnecessary treatments. This paper reviews the physiological and pathological processes involved as well as the strategy to recognize and rule out false positive radioiodine images.

Original languageEnglish
JournalEndocrine
DOIs
Publication statusAccepted/In press - Oct 26 2015

Keywords

  • Iodine
  • Differentiated thyroid cancer
  • Metastatic thyroid cancer
  • Natrium/iodide symporter
  • Radioiodine uptake
  • Thyroid scintigraphy
  • Whole-body scintigraphy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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    Triggiani, V., Giagulli, V. A., Iovino, M., de Pergola, G., Licchelli, B., Varraso, A., Dicembrino, F., Valle, G., & Guastamacchia, E. (Accepted/In press). False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers. Endocrine. https://doi.org/10.1007/s12020-015-0750-3