False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers

Vincenzo Triggiani, Vito Angelo Giagulli, Michele Iovino, Giovanni de Pergola, Brunella Licchelli, Antonio Varraso, Franca Dicembrino, Guido Valle, Edoardo Guastamacchia

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

131Iodine is used both to ablate any residual thyroid tissue or metastatic disease and to obtain whole-body diagnostic images after total thyroidectomy for differentiated thyroid cancer (DTC). Even though whole-body scan is highly accurate in showing thyroid residues as well as metastases of DTC, false positive results can be found, possibly leading to diagnostic errors and unnecessary treatments. This paper reviews the physiological and pathological processes involved as well as the strategy to recognize and rule out false positive radioiodine images.

Original languageEnglish
JournalEndocrine
DOIs
Publication statusAccepted/In press - Oct 26 2015

Fingerprint

Thyroid Neoplasms
Radionuclide Imaging
Thyroid Gland
Physiological Phenomena
Whole Body Imaging
Body Image
Thyroidectomy
Pathologic Processes
Diagnostic Errors
Neoplasm Metastasis

Keywords

  • Iodine
  • Differentiated thyroid cancer
  • Metastatic thyroid cancer
  • Natrium/iodide symporter
  • Radioiodine uptake
  • Thyroid scintigraphy
  • Whole-body scintigraphy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Triggiani, V., Giagulli, V. A., Iovino, M., de Pergola, G., Licchelli, B., Varraso, A., ... Guastamacchia, E. (Accepted/In press). False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers. Endocrine. https://doi.org/10.1007/s12020-015-0750-3

False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers. / Triggiani, Vincenzo; Giagulli, Vito Angelo; Iovino, Michele; de Pergola, Giovanni; Licchelli, Brunella; Varraso, Antonio; Dicembrino, Franca; Valle, Guido; Guastamacchia, Edoardo.

In: Endocrine, 26.10.2015.

Research output: Contribution to journalArticle

Triggiani, V, Giagulli, VA, Iovino, M, de Pergola, G, Licchelli, B, Varraso, A, Dicembrino, F, Valle, G & Guastamacchia, E 2015, 'False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers', Endocrine. https://doi.org/10.1007/s12020-015-0750-3
Triggiani V, Giagulli VA, Iovino M, de Pergola G, Licchelli B, Varraso A et al. False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers. Endocrine. 2015 Oct 26. https://doi.org/10.1007/s12020-015-0750-3
Triggiani, Vincenzo ; Giagulli, Vito Angelo ; Iovino, Michele ; de Pergola, Giovanni ; Licchelli, Brunella ; Varraso, Antonio ; Dicembrino, Franca ; Valle, Guido ; Guastamacchia, Edoardo. / False positive diagnosis on 131iodine whole-body scintigraphy of differentiated thyroid cancers. In: Endocrine. 2015.
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