False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam

Claudio Viscoli, Marco Machetti, Paola Cappellano, Barbara Bucci, Paolo Bruzzi, Maria Teresa Van Lint, Andrea Bacigalupo

Research output: Contribution to journalArticlepeer-review

Abstract

At the bone marrow transplantation center of the San Martino Hospital (Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% (38 of 386 patients) in the period from January 1999 through January 2003 to 36% (21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P <.001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT (χ2 = 34.7; P<.001) and underlying disease (χ2 = 21.14; P <.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results.

Original languageEnglish
Pages (from-to)913-916
Number of pages4
JournalClinical Infectious Diseases
Volume38
Issue number6
DOIs
Publication statusPublished - Mar 15 2004

ASJC Scopus subject areas

  • Immunology

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