'False-positive' myocardial perfusion imaging

Correlation with cardiovascular risk factors and effect on event-free survival

Alessia Gimelli, Paolo Marzullo, Antonio LAbbate, Daniele Rovai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: In the absence of significant coronary stenoses, stress-induced myocardial perfusion abnormalities at gated single photon emission computed tomography (g-SPECT) are usually considered to be a 'false-positive' result. Our goal was to investigate how false-positive g-SPECT perfusion abnormalities relate to cardiovascular risk factors and whether they provide any prognostic information. METHODS: From 1999 to 2005, a group of 130 anginal patients with myocardial perfusion abnormalities at stress g-SPECT, with normal coronary angiography or less than 50% lumen reduction and with a left ventricular ejection fraction more than 0.45, was selected. The extent of myocardial perfusion abnormalities after stress was quantified using the summed difference score (SDS). RESULTS: Using a logistic regression model, it was found that cardiovascular risk factors (diabetes mellitus, arterial hypertension, smoking habit, hypercholesterolemia and obesity) were closely related (r = 0.96) to the SDS. During a 44 ± 7-month follow-up, six patients experienced nonfatal cardiac events. An SDS more than 7 (P <0.0001) and diabetes mellitus (P <0.0001) were the only independent predictors of event-free survival using Cox proportional hazard regression analysis. CONCLUSION: In patients with anginal-like chest pain and without significant coronary stenoses, stress-induced myocardial perfusion abnormalities at g-SPECT correlate with cardiovascular risk factors and are independent predictors of the few, minor adverse cardiac events during the follow-up.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalJournal of Cardiovascular Medicine
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2008

Fingerprint

Myocardial Perfusion Imaging
Disease-Free Survival
Single-Photon Emission-Computed Tomography
Perfusion
Coronary Stenosis
Diabetes Mellitus
Logistic Models
Hypercholesterolemia
Coronary Angiography
Chest Pain
Stroke Volume
Habits
Obesity
Smoking
Regression Analysis
Hypertension

Keywords

  • Angina
  • Cardiovascular risk factors
  • Myocardial perfusion
  • Prognosis
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

'False-positive' myocardial perfusion imaging : Correlation with cardiovascular risk factors and effect on event-free survival. / Gimelli, Alessia; Marzullo, Paolo; LAbbate, Antonio; Rovai, Daniele.

In: Journal of Cardiovascular Medicine, Vol. 9, No. 7, 07.2008, p. 707-713.

Research output: Contribution to journalArticle

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