FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis

M S Chattaragada, C Riganti, M Sassoe, M Principe, M M Santamorena, C Roux, C Curcio, A Evangelista, P Allavena, R Salvia, B Rusev, A Scarpa, P Cappello, F Novelli

Research output: Contribution to journalArticle

Abstract

Mitochondrial dysregulation plays a central role in cancers and drives reactive oxygen species (ROS)-dependent tumor progression. We investigated the pro-tumoral roles of mitochondrial dynamics and altered intracellular ROS levels in pancreatic ductal adenocarcinoma (PDAC). We identified 'family with sequence similarity 49 member B' (FAM49B) as a mitochondria-localized protein that regulates mitochondrial fission and cancer progression. Silencing FAM49B in PDAC cells resulted in increased fission and mitochondrial ROS generation, which enhanced PDAC cell proliferation and invasion. Notably, FAM49B expression levels in PDAC cells were downregulated by the tumor microenvironment. Overall, the results of this study show that FAM49B acts as a suppressor of cancer cell proliferation and invasion in PDAC by regulating tumor mitochondrial redox reactions and metabolism.

Original languageEnglish
Pages (from-to)697-709
Number of pages13
JournalOncogene
Volume37
Issue number6
DOIs
Publication statusPublished - Feb 8 2018

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Mitochondrial Dynamics
Adenocarcinoma
Neoplasm Metastasis
Reactive Oxygen Species
Neoplasms
Cell Proliferation
Tumor Microenvironment
Oxidation-Reduction
Mitochondria
Down-Regulation
Proteins

Keywords

  • Journal Article

Cite this

Chattaragada, M. S., Riganti, C., Sassoe, M., Principe, M., Santamorena, M. M., Roux, C., ... Novelli, F. (2018). FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Oncogene, 37(6), 697-709. https://doi.org/10.1038/onc.2017.358

FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. / Chattaragada, M S; Riganti, C; Sassoe, M; Principe, M; Santamorena, M M; Roux, C; Curcio, C; Evangelista, A; Allavena, P; Salvia, R; Rusev, B; Scarpa, A; Cappello, P; Novelli, F.

In: Oncogene, Vol. 37, No. 6, 08.02.2018, p. 697-709.

Research output: Contribution to journalArticle

Chattaragada, MS, Riganti, C, Sassoe, M, Principe, M, Santamorena, MM, Roux, C, Curcio, C, Evangelista, A, Allavena, P, Salvia, R, Rusev, B, Scarpa, A, Cappello, P & Novelli, F 2018, 'FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis', Oncogene, vol. 37, no. 6, pp. 697-709. https://doi.org/10.1038/onc.2017.358
Chattaragada MS, Riganti C, Sassoe M, Principe M, Santamorena MM, Roux C et al. FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Oncogene. 2018 Feb 8;37(6):697-709. https://doi.org/10.1038/onc.2017.358
Chattaragada, M S ; Riganti, C ; Sassoe, M ; Principe, M ; Santamorena, M M ; Roux, C ; Curcio, C ; Evangelista, A ; Allavena, P ; Salvia, R ; Rusev, B ; Scarpa, A ; Cappello, P ; Novelli, F. / FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. In: Oncogene. 2018 ; Vol. 37, No. 6. pp. 697-709.
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