La poliposi adenomatosa familiare. Problemi offerti dalla conservazione del retto nel trattamento chirurgico ed aspettative di vita.

Translated title of the contribution: Familial adenomatous polyposis. Problems encountered with rectum preservation in surgical treatment and life expectancy

P. L. Colombo, C. S. Foglieni, V. Marzo, E. Negri, C. Bianchi, A. M. Sciutto, M. A. Plantera, M. Belisomo, S. Tinozzi

Research output: Contribution to journalArticle

Abstract

Familial adenomatous polyposis is a genetically inherited disease with very high risk of colorectal cancer and with a large expression of multiple extracolonic malignancies. In recent years two surgical options are available for the treatment of FAP: total colectomy with ileorectal anastomosis and restorative proctocolectomy with ileoanal reservoir. The preservation of the rectum offers good quality of life and good functional results, but needs an accurate surveillance of the rectal stump and screening for the development of cancer. Restorative proctocolectomy is reserved for patients with large or confluent polyps of the rectum, for older patients and for those who had already had an ileorectal anastomosis and who develops subsequently large adenomas at increased risk for rectal cancer. Prophylactic procedures of surveillance, screening and surgery have reduced in patients at risk the incidence of colorectal cancer. But recently an increased number of malignant extracolonic tumors (gastric cancer, duodenal and periampullary cancer, small intestinal cancer, adrenal and thyroid cancer) and abdominal desmoid tumors, that causes a significant mortality, has been documented. The knowledge of the extracolonic features of FAP suggests a careful follow-up of the patients and the prevention and treatment of upper gastrointestinal cancers and desmoid disease.

Original languageItalian
Pages (from-to)671-683
Number of pages13
JournalAnnali Italiani di Chirurgia
Volume66
Issue number5
Publication statusPublished - Sep 1995

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Adenomatous Polyposis Coli
Life Expectancy
Rectum
Restorative Proctocolectomy
Aggressive Fibromatosis
Thyroid Neoplasms
Colorectal Neoplasms
Adrenal Gland Neoplasms
Duodenal Neoplasms
Intestinal Neoplasms
Colonic Pouches
Neoplasms
Gastrointestinal Neoplasms
Colectomy
Therapeutics
Rectal Neoplasms
Polyps
Early Detection of Cancer
Adenoma
Stomach Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

La poliposi adenomatosa familiare. Problemi offerti dalla conservazione del retto nel trattamento chirurgico ed aspettative di vita. / Colombo, P. L.; Foglieni, C. S.; Marzo, V.; Negri, E.; Bianchi, C.; Sciutto, A. M.; Plantera, M. A.; Belisomo, M.; Tinozzi, S.

In: Annali Italiani di Chirurgia, Vol. 66, No. 5, 09.1995, p. 671-683.

Research output: Contribution to journalArticle

Colombo, PL, Foglieni, CS, Marzo, V, Negri, E, Bianchi, C, Sciutto, AM, Plantera, MA, Belisomo, M & Tinozzi, S 1995, 'La poliposi adenomatosa familiare. Problemi offerti dalla conservazione del retto nel trattamento chirurgico ed aspettative di vita.', Annali Italiani di Chirurgia, vol. 66, no. 5, pp. 671-683.
Colombo, P. L. ; Foglieni, C. S. ; Marzo, V. ; Negri, E. ; Bianchi, C. ; Sciutto, A. M. ; Plantera, M. A. ; Belisomo, M. ; Tinozzi, S. / La poliposi adenomatosa familiare. Problemi offerti dalla conservazione del retto nel trattamento chirurgico ed aspettative di vita. In: Annali Italiani di Chirurgia. 1995 ; Vol. 66, No. 5. pp. 671-683.
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