Familial aggregation of moderate to severe plaque psoriasis

Vito Di Lernia, E. Ficarelli, A. Lallas, C. Ricci

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Psoriasis is a highly heritable disease. It has been suggested that psoriasis is preferentially transmitted from fathers. Aim. To evaluate the degree of familial aggregation of psoriasis; to determine the recurrence risk ratio (λR) of psoriasis in first, second and third degree relatives of patients with psoriasis; and to investigate the transmission patterns of the disease and their relationships with the clinical profiles of patients. Methods. A cross-sectional study on 640 consecutive, unrelated adult patients with chronic plaque psoriasis was performed. The prevalence of psoriasis in first, second and third degree relatives of the patients was determined, and the kR was calculated under the assumption of a population prevalence of 2%. Age of onset and presence of facial, hand and foot psoriasis were evaluated in probands with paternal vs. maternal transmission. Results. A positive familial history of psoriasis was found in 380 patients (59.37%). Of these, 174 (27.18%) had at least one parent with psoriasis, with a kR of 13.59, while 106 patients (16.56%) had at least one second degree relative with psoriasis, and 34 patients (5.31%) had one third degree relative with psoriasis. No parent-of-origin effect in transmission of psoriasis from affected parent to offspring was observed, and there were no significant differences in the clinical profiles of the disease between patients grouped by transmission pattern of psoriasis. Conclusions. These results show a high familial recurrence risk of psoriasis, and suggest a balanced parental transmission of the disease.

Original languageEnglish
Pages (from-to)801-805
Number of pages5
JournalClinical and Experimental Dermatology
Volume39
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Psoriasis
Recurrence
Age of Onset
Fathers
Foot
Hand
Cross-Sectional Studies
Odds Ratio

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Familial aggregation of moderate to severe plaque psoriasis. / Di Lernia, Vito; Ficarelli, E.; Lallas, A.; Ricci, C.

In: Clinical and Experimental Dermatology, Vol. 39, No. 7, 2014, p. 801-805.

Research output: Contribution to journalArticle

@article{6e911bf3f3774d16b761062486f24674,
title = "Familial aggregation of moderate to severe plaque psoriasis",
abstract = "Background. Psoriasis is a highly heritable disease. It has been suggested that psoriasis is preferentially transmitted from fathers. Aim. To evaluate the degree of familial aggregation of psoriasis; to determine the recurrence risk ratio (λR) of psoriasis in first, second and third degree relatives of patients with psoriasis; and to investigate the transmission patterns of the disease and their relationships with the clinical profiles of patients. Methods. A cross-sectional study on 640 consecutive, unrelated adult patients with chronic plaque psoriasis was performed. The prevalence of psoriasis in first, second and third degree relatives of the patients was determined, and the kR was calculated under the assumption of a population prevalence of 2{\%}. Age of onset and presence of facial, hand and foot psoriasis were evaluated in probands with paternal vs. maternal transmission. Results. A positive familial history of psoriasis was found in 380 patients (59.37{\%}). Of these, 174 (27.18{\%}) had at least one parent with psoriasis, with a kR of 13.59, while 106 patients (16.56{\%}) had at least one second degree relative with psoriasis, and 34 patients (5.31{\%}) had one third degree relative with psoriasis. No parent-of-origin effect in transmission of psoriasis from affected parent to offspring was observed, and there were no significant differences in the clinical profiles of the disease between patients grouped by transmission pattern of psoriasis. Conclusions. These results show a high familial recurrence risk of psoriasis, and suggest a balanced parental transmission of the disease.",
author = "{Di Lernia}, Vito and E. Ficarelli and A. Lallas and C. Ricci",
year = "2014",
doi = "10.1111/ced.12401",
language = "English",
volume = "39",
pages = "801--805",
journal = "Clinical and Experimental Dermatology",
issn = "0307-6938",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Familial aggregation of moderate to severe plaque psoriasis

AU - Di Lernia, Vito

AU - Ficarelli, E.

AU - Lallas, A.

AU - Ricci, C.

PY - 2014

Y1 - 2014

N2 - Background. Psoriasis is a highly heritable disease. It has been suggested that psoriasis is preferentially transmitted from fathers. Aim. To evaluate the degree of familial aggregation of psoriasis; to determine the recurrence risk ratio (λR) of psoriasis in first, second and third degree relatives of patients with psoriasis; and to investigate the transmission patterns of the disease and their relationships with the clinical profiles of patients. Methods. A cross-sectional study on 640 consecutive, unrelated adult patients with chronic plaque psoriasis was performed. The prevalence of psoriasis in first, second and third degree relatives of the patients was determined, and the kR was calculated under the assumption of a population prevalence of 2%. Age of onset and presence of facial, hand and foot psoriasis were evaluated in probands with paternal vs. maternal transmission. Results. A positive familial history of psoriasis was found in 380 patients (59.37%). Of these, 174 (27.18%) had at least one parent with psoriasis, with a kR of 13.59, while 106 patients (16.56%) had at least one second degree relative with psoriasis, and 34 patients (5.31%) had one third degree relative with psoriasis. No parent-of-origin effect in transmission of psoriasis from affected parent to offspring was observed, and there were no significant differences in the clinical profiles of the disease between patients grouped by transmission pattern of psoriasis. Conclusions. These results show a high familial recurrence risk of psoriasis, and suggest a balanced parental transmission of the disease.

AB - Background. Psoriasis is a highly heritable disease. It has been suggested that psoriasis is preferentially transmitted from fathers. Aim. To evaluate the degree of familial aggregation of psoriasis; to determine the recurrence risk ratio (λR) of psoriasis in first, second and third degree relatives of patients with psoriasis; and to investigate the transmission patterns of the disease and their relationships with the clinical profiles of patients. Methods. A cross-sectional study on 640 consecutive, unrelated adult patients with chronic plaque psoriasis was performed. The prevalence of psoriasis in first, second and third degree relatives of the patients was determined, and the kR was calculated under the assumption of a population prevalence of 2%. Age of onset and presence of facial, hand and foot psoriasis were evaluated in probands with paternal vs. maternal transmission. Results. A positive familial history of psoriasis was found in 380 patients (59.37%). Of these, 174 (27.18%) had at least one parent with psoriasis, with a kR of 13.59, while 106 patients (16.56%) had at least one second degree relative with psoriasis, and 34 patients (5.31%) had one third degree relative with psoriasis. No parent-of-origin effect in transmission of psoriasis from affected parent to offspring was observed, and there were no significant differences in the clinical profiles of the disease between patients grouped by transmission pattern of psoriasis. Conclusions. These results show a high familial recurrence risk of psoriasis, and suggest a balanced parental transmission of the disease.

UR - http://www.scopus.com/inward/record.url?scp=84927562148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927562148&partnerID=8YFLogxK

U2 - 10.1111/ced.12401

DO - 10.1111/ced.12401

M3 - Article

C2 - 25156221

AN - SCOPUS:84927562148

VL - 39

SP - 801

EP - 805

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

SN - 0307-6938

IS - 7

ER -