TY - JOUR
T1 - Familial aggregation of pure tone hearing thresholds in an aging European population
AU - Hendrickx, Jan Jaap
AU - Huyghe, Jeroen R.
AU - Topsakal, Vedat
AU - Demeester, Kelly
AU - Wienker, Thomas F.
AU - Van Laer, Lut
AU - Van Eyken, Els
AU - Fransen, Erik
AU - Mäki-Torkko, Elina
AU - Hannula, Samuli
AU - Parving, Agnete
AU - Jensen, Mona
AU - Tropitzsch, Anke
AU - Bonaconsa, Amanda
AU - Mazzoli, Manuela
AU - Espeso, Angeles
AU - Verbruggen, Katja
AU - Huyghe, Joke
AU - Huygen, Patrick L M
AU - Kremer, Hannie
AU - Kunst, Sylvia J.
AU - Diaz-Lacava, Amalia N.
AU - Steffens, Michael
AU - Pyykkö, Ilmari
AU - Dhooge, Ingeborg
AU - Stephens, Dafydd
AU - Orzan, Eva
AU - Pfister, Markus H F
AU - Bille, Michael
AU - Sorri, Martti
AU - Cremers, Cor W R J
AU - Van Camp, Guy
AU - Van De Heyning, Paul
PY - 2013/7
Y1 - 2013/7
N2 - OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated. STUDY DESIGN: Multicenter survey in 8 European centers. SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study. RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies. DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.
AB - OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated. STUDY DESIGN: Multicenter survey in 8 European centers. SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study. RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies. DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.
KW - Age-related hearing impairment
KW - Genetics
KW - Heritability
KW - Pure tone audiometry
KW - Sensorineural hearing loss
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U2 - 10.1097/MAO.0b013e318288646a
DO - 10.1097/MAO.0b013e318288646a
M3 - Article
C2 - 23739559
AN - SCOPUS:84880923408
VL - 34
SP - 838
EP - 844
JO - Otology and Neurotology
JF - Otology and Neurotology
SN - 1531-7129
IS - 5
ER -