Abstract
Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.
| Original language | English |
|---|---|
| Pages (from-to) | 255-259 |
| Number of pages | 5 |
| Journal | Journal of Psychiatric Research |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 1998 |
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Keywords
- Antidepressant response
- Bipolar disorder
- Mood disorder
- Morbidity risk
- Pharmacogenetics
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees. / Franchini, Linda; Serretti, Alessandro; Gasperini, Mariangela; Smeraldi, Enrico.
In: Journal of Psychiatric Research, Vol. 32, No. 5, 09.1998, p. 255-259.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees
AU - Franchini, Linda
AU - Serretti, Alessandro
AU - Gasperini, Mariangela
AU - Smeraldi, Enrico
PY - 1998/9
Y1 - 1998/9
N2 - Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.
AB - Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.
KW - Antidepressant response
KW - Bipolar disorder
KW - Mood disorder
KW - Morbidity risk
KW - Pharmacogenetics
UR - http://www.scopus.com/inward/record.url?scp=0032167874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032167874&partnerID=8YFLogxK
U2 - 10.1016/S0022-3956(98)00004-1
DO - 10.1016/S0022-3956(98)00004-1
M3 - Article
C2 - 9789202
AN - SCOPUS:0032167874
VL - 32
SP - 255
EP - 259
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
IS - 5
ER -