Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees

Linda Franchini, Alessandro Serretti, Mariangela Gasperini, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalJournal of Psychiatric Research
Volume32
Issue number5
DOIs
Publication statusPublished - Sep 1998

Keywords

  • Antidepressant response
  • Bipolar disorder
  • Mood disorder
  • Morbidity risk
  • Pharmacogenetics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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