Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees

Linda Franchini; Alessandro Serretti; Mariangela Gasperini; Enrico Smeraldi

doi:10.1016/S0022-3956(98)00004-1

Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees

Linda Franchini, Alessandro Serretti, Mariangela Gasperini, Enrico Smeraldi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.

Original language	English
Pages (from-to)	255-259
Number of pages	5
Journal	Journal of Psychiatric Research
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3956(98)00004-1
Publication status	Published - Sep 1998

Keywords

Antidepressant response
Bipolar disorder
Mood disorder
Morbidity risk
Pharmacogenetics

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Psychology(all)

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abstract = "Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.",

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