Abstract
Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.
Original language | English |
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Pages (from-to) | 255-259 |
Number of pages | 5 |
Journal | Journal of Psychiatric Research |
Volume | 32 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 1998 |
Keywords
- Antidepressant response
- Bipolar disorder
- Mood disorder
- Morbidity risk
- Pharmacogenetics
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)