Familial concordance of SSRIs response as a tool for differentiating mood disorder pedigrees

L. Franchini, A. Serretti, E. Smeraldi

Research output: Contribution to journalArticlepeer-review


Concordance to antidepressant response in members of the same family is a common observation in clinical practice, but up to now familial response concordance has never been used for genetic purposes. In the present study in a sample of fluvoxamine double-responder probands we have evaluated the rate of good response concordance among their first degree relatives. Moreover, we have evaluated the genetic load expressed as morbidity risk for Mood Disorder in the pedigrees according to concordant/non concordant fluvoxamine response. We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9 vs 3.9% p=0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading.

Original languageEnglish
Pages (from-to)536
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number4
Publication statusPublished - Aug 7 2000

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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