IL DEFICIT FAMILIARE DELLE ALFALIPOPROTEINE. LA MALATTIA DI TANGIER, L'IPOALFALIPOPROTEINEMIA FAMILIARE, IL DEFICIT FAMILIARE DELLA LECITINCOLESTEROLO ACILTRANSFERASI

Translated title of the contribution: Familial deficiency of alphalipoproteins. Tangier disease, familial hypoalphalipoproteinaemia and familial lecithincholesterol acyltransferase deficiency

N. Dioguardi, C. Vergani

Research output: Contribution to journalArticle

Abstract

The plasma lipoproteins are a group of macromolecules all of which transport lipids, including cholesterol, triglyceride and phospholipid, and all of which have one or more protein constituentss called apoproteins. It is becoming apparent that the apoproteins play an important role in lipoprotein metabolism. Recently the so called 'alpha hypothesis' has been proposed, according to which a protective role for HDL in atherosclerosis has been postulated. Three 'experiments of nature', characterized by deficiences of HDL as genetic disorders, namely Tangier disease, familial hypoalphalipoproteinemia, familial lecithin: cholesterol acetyltransferase deficiency, support the the 'alpha hypothesis'. The first Italian cases with the genetic disorders are presented.

Translated title of the contributionFamilial deficiency of alphalipoproteins. Tangier disease, familial hypoalphalipoproteinaemia and familial lecithincholesterol acyltransferase deficiency
Original languageItalian
Pages (from-to)585-594
Number of pages10
JournalMinerva Medica
Volume74
Issue number12
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)

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