Familial elevation of serum angiotensin converting enzyme activity

M. Luisetti, M. Martinetti, M. Cuccia, J. M. Dugoujon, V. De Rose, V. Peona, E. Pozzi, C. Grassi

Research output: Contribution to journalArticle

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Abstract

A clustering of high levels of serum angiotensin converting enzyme (S-ACE) was found in an Italian family. The elevation affected five subjects, two of whom were completely healthy and free from known causes of S-ACE increase. The values of S-ACE in hyperACEmic subjects exceeded the values found in normal relatives several-fold. HyperACEmia seemed to be inherited as an autosomal dominant trait. Immunogenetic studies were performed, but we did not find a genetic marker for this condition. The S-ACE activity was inhibited in vitro by edetic acid (EDTA) and SQ 14,225 (captopril). The S-ACE activity was also determined after 1:8 dilution and dialysis against saline of sera. From these experiments we deduced that Lieberman's intrinsic ACE inhibitor was lacking in the hyperACEmic sera. In the presence of remarkable S-ACE increase, a congenital elevation of S-ACE should be considered and it would be useful to perform a familial investigation.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalEuropean Respiratory Journal
Volume3
Issue number4
Publication statusPublished - 1990

Fingerprint

Peptidyl-Dipeptidase A
Serum
Captopril
Immunogenetics
Genetic Markers
Angiotensin-Converting Enzyme Inhibitors
Edetic Acid
Cluster Analysis
Dialysis

Keywords

  • Alpha-antitrypsin typing
  • Gm, Km immunoglobulin allotypes
  • HLA polymorphisms
  • interstitial lung disease
  • intrinsic serum angiotensin converting enzyme (S-ACE) inhibitor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Luisetti, M., Martinetti, M., Cuccia, M., Dugoujon, J. M., De Rose, V., Peona, V., ... Grassi, C. (1990). Familial elevation of serum angiotensin converting enzyme activity. European Respiratory Journal, 3(4), 441-446.

Familial elevation of serum angiotensin converting enzyme activity. / Luisetti, M.; Martinetti, M.; Cuccia, M.; Dugoujon, J. M.; De Rose, V.; Peona, V.; Pozzi, E.; Grassi, C.

In: European Respiratory Journal, Vol. 3, No. 4, 1990, p. 441-446.

Research output: Contribution to journalArticle

Luisetti, M, Martinetti, M, Cuccia, M, Dugoujon, JM, De Rose, V, Peona, V, Pozzi, E & Grassi, C 1990, 'Familial elevation of serum angiotensin converting enzyme activity', European Respiratory Journal, vol. 3, no. 4, pp. 441-446.
Luisetti M, Martinetti M, Cuccia M, Dugoujon JM, De Rose V, Peona V et al. Familial elevation of serum angiotensin converting enzyme activity. European Respiratory Journal. 1990;3(4):441-446.
Luisetti, M. ; Martinetti, M. ; Cuccia, M. ; Dugoujon, J. M. ; De Rose, V. ; Peona, V. ; Pozzi, E. ; Grassi, C. / Familial elevation of serum angiotensin converting enzyme activity. In: European Respiratory Journal. 1990 ; Vol. 3, No. 4. pp. 441-446.
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