Familial elevation of serum angiotensin converting enzyme activity

M. Luisetti, M. Martinetti, M. Cuccia, J. M. Dugoujon, V. De Rose, V. Peona, E. Pozzi, C. Grassi

Research output: Contribution to journalArticlepeer-review


A clustering of high levels of serum angiotensin converting enzyme (S-ACE) was found in an Italian family. The elevation affected five subjects, two of whom were completely healthy and free from known causes of S-ACE increase. The values of S-ACE in hyperACEmic subjects exceeded the values found in normal relatives several-fold. HyperACEmia seemed to be inherited as an autosomal dominant trait. Immunogenetic studies were performed, but we did not find a genetic marker for this condition. The S-ACE activity was inhibited in vitro by edetic acid (EDTA) and SQ 14,225 (captopril). The S-ACE activity was also determined after 1:8 dilution and dialysis against saline of sera. From these experiments we deduced that Lieberman's intrinsic ACE inhibitor was lacking in the hyperACEmic sera. In the presence of remarkable S-ACE increase, a congenital elevation of S-ACE should be considered and it would be useful to perform a familial investigation.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalEuropean Respiratory Journal
Issue number4
Publication statusPublished - 1990


  • Alpha-antitrypsin typing
  • Gm, Km immunoglobulin allotypes
  • HLA polymorphisms
  • interstitial lung disease
  • intrinsic serum angiotensin converting enzyme (S-ACE) inhibitor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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