Familial gastric cancer and Li-Fraumeni syndrome

G. Corso, C. Pedrazzani, D. Marrelli, E. Pinto, F. Roviello

Research output: Contribution to journalArticle

Abstract

Gastric cancer occurs in some familial diseases with inherited cancer predisposition. Genetic factors have been correlated with the hereditary diffuse gastric cancer and other familial gastric cancer conditions as hereditary non-polyposis colorectal cancer and Li-Fraumeni syndrome. The present study was aimed at searching for germ line mutations of TP53 gene in familial gastric cancer with cluster for Li-Fraumeni syndrome or Li-Fraumeni-like syndrome. Twenty-three pedigrees with characteristics for Li-Fraumeni-like syndrome were identified. DNA of the proband was sequenced using polymerase chain reaction/single-strand conformation polymorphism. Among these 23 cases, no germ line mutation of TP53 was identified, while two single-nucleotide polymorphisms were identified in four patients. In our area, in which a high rate of familial aggregation was demonstrated, the lack of germ line mutation of TP53 together with the infrequency of mutation of E-cadherin gene seem to limit the role of genetic predisposition in the development of gastric cancer.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalEuropean Journal of Cancer Care
Volume19
Issue number3
DOIs
Publication statusPublished - May 2010

Fingerprint

Li-Fraumeni Syndrome
Stomach Neoplasms
Germ-Line Mutation
p53 Genes
Cadherins
Pedigree
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
Colorectal Neoplasms
Polymerase Chain Reaction
Mutation
DNA
Genes
Neoplasms

Keywords

  • Germ line mutation
  • Li-Fraumeni syndrome
  • TP53

ASJC Scopus subject areas

  • Oncology

Cite this

Familial gastric cancer and Li-Fraumeni syndrome. / Corso, G.; Pedrazzani, C.; Marrelli, D.; Pinto, E.; Roviello, F.

In: European Journal of Cancer Care, Vol. 19, No. 3, 05.2010, p. 377-381.

Research output: Contribution to journalArticle

Corso, G, Pedrazzani, C, Marrelli, D, Pinto, E & Roviello, F 2010, 'Familial gastric cancer and Li-Fraumeni syndrome', European Journal of Cancer Care, vol. 19, no. 3, pp. 377-381. https://doi.org/10.1111/j.1365-2354.2008.01066.x
Corso, G. ; Pedrazzani, C. ; Marrelli, D. ; Pinto, E. ; Roviello, F. / Familial gastric cancer and Li-Fraumeni syndrome. In: European Journal of Cancer Care. 2010 ; Vol. 19, No. 3. pp. 377-381.
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