Emicrania emiplegica famigliare: Probabile linkage al cromosoma 1 ed eterogeneità genetica

Translated title of the contribution: Familial hemiplegic migraine: Probable linkage to chromosome 1 and genetic heterogeneity

S. Cevoli, L. Monari, M. L. Valentino, G. Pierangeli, P. Bernardoni, F. Granella, S. Soriani, M. Mochi, P. Cortelli, P. Montagna

Research output: Contribution to journalArticle

Abstract

Familial hemiplegic migraine (FHM) is an autosomal dominant form of migraine with aura. FHM is genetically heterogeneous. In about 50% of families FHM is caused by mutations in the CACNA1A gene on chromosome 19. Linkage to 1q31 e 1q21-23 has also been established. We observed two Italian families both unlinked to chromosome 19. In one family with probable linkage to chromosome 1q21-23, some affected members showed cerebellar signs, previously reported only in families linked to chromosome 19. Our families confirms the genetic heterogeneity of FHM.

Original languageItalian
Pages (from-to)117-121
Number of pages5
JournalConfinia Cephalalgica
Volume9
Issue number3
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Clinical Neurology

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