Abstract
The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.
| Original language | English |
|---|---|
| Pages (from-to) | 21-24 |
| Number of pages | 4 |
| Journal | Acta Paediatrica, International Journal of Paediatrics |
| Volume | 81 |
| Issue number | 1 |
| Publication status | Published - 1992 |
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Keywords
- cholesterol screening
- cord blood lipids
- neonates
- risk of cardiovascular disease
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Familial history of cardiovascular disease and blood lipid pattern in newborn infants. / Bellu, R.; Ortisi, M. T.; Agostoni, C.; Incerti, P.; Besana, R.; Riva, E.; Giovannini, M.
In: Acta Paediatrica, International Journal of Paediatrics, Vol. 81, No. 1, 1992, p. 21-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial history of cardiovascular disease and blood lipid pattern in newborn infants
AU - Bellu, R.
AU - Ortisi, M. T.
AU - Agostoni, C.
AU - Incerti, P.
AU - Besana, R.
AU - Riva, E.
AU - Giovannini, M.
PY - 1992
Y1 - 1992
N2 - The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.
AB - The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.
KW - cholesterol screening
KW - cord blood lipids
KW - neonates
KW - risk of cardiovascular disease
UR - http://www.scopus.com/inward/record.url?scp=0026516738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026516738&partnerID=8YFLogxK
M3 - Article
C2 - 1600298
AN - SCOPUS:0026516738
VL - 81
SP - 21
EP - 24
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
SN - 0803-5253
IS - 1
ER -