Familial history of cardiovascular disease and blood lipid pattern in newborn infants

R. Bellu, M. T. Ortisi, C. Agostoni, P. Incerti, R. Besana, E. Riva, M. Giovannini

Research output: Contribution to journalArticlepeer-review


The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Issue number1
Publication statusPublished - 1992


  • cholesterol screening
  • cord blood lipids
  • neonates
  • risk of cardiovascular disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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