Familial history of cardiovascular disease and blood lipid pattern in newborn infants

R. Bellu; M. T. Ortisi; C. Agostoni; P. Incerti; R. Besana; E. Riva; M. Giovannini

Familial history of cardiovascular disease and blood lipid pattern in newborn infants

R. Bellu, M. T. Ortisi, C. Agostoni, P. Incerti, R. Besana, E. Riva, M. Giovannini

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	81
Issue number	1
Publication status	Published - 1992

Keywords

cholesterol screening
cord blood lipids
neonates
risk of cardiovascular disease

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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abstract = "The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.",

keywords = "cholesterol screening, cord blood lipids, neonates, risk of cardiovascular disease",

author = "R. Bellu and Ortisi, {M. T.} and C. Agostoni and P. Incerti and R. Besana and E. Riva and M. Giovannini",

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T1 - Familial history of cardiovascular disease and blood lipid pattern in newborn infants

AU - Bellu, R.

AU - Ortisi, M. T.

AU - Agostoni, C.

AU - Incerti, P.

AU - Besana, R.

AU - Riva, E.

AU - Giovannini, M.

PY - 1992

Y1 - 1992

N2 - The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.

AB - The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.

KW - cholesterol screening

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KW - risk of cardiovascular disease

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