Familial history of cardiovascular disease and blood lipid pattern in newborn infants

R. Bellu, M. T. Ortisi, C. Agostoni, P. Incerti, R. Besana, E. Riva, M. Giovannini

Research output: Contribution to journalArticle

Abstract

The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P <0.04) and LDL-C (P <0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume81
Issue number1
Publication statusPublished - 1992

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LDL Cholesterol
Cardiovascular Diseases
Fetal Blood
Cholesterol
Newborn Infant
Lipids
Triglycerides
HDL Cholesterol
Coronary Disease

Keywords

  • cholesterol screening
  • cord blood lipids
  • neonates
  • risk of cardiovascular disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bellu, R., Ortisi, M. T., Agostoni, C., Incerti, P., Besana, R., Riva, E., & Giovannini, M. (1992). Familial history of cardiovascular disease and blood lipid pattern in newborn infants. Acta Paediatrica, International Journal of Paediatrics, 81(1), 21-24.

Familial history of cardiovascular disease and blood lipid pattern in newborn infants. / Bellu, R.; Ortisi, M. T.; Agostoni, C.; Incerti, P.; Besana, R.; Riva, E.; Giovannini, M.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 81, No. 1, 1992, p. 21-24.

Research output: Contribution to journalArticle

Bellu, R, Ortisi, MT, Agostoni, C, Incerti, P, Besana, R, Riva, E & Giovannini, M 1992, 'Familial history of cardiovascular disease and blood lipid pattern in newborn infants', Acta Paediatrica, International Journal of Paediatrics, vol. 81, no. 1, pp. 21-24.
Bellu, R. ; Ortisi, M. T. ; Agostoni, C. ; Incerti, P. ; Besana, R. ; Riva, E. ; Giovannini, M. / Familial history of cardiovascular disease and blood lipid pattern in newborn infants. In: Acta Paediatrica, International Journal of Paediatrics. 1992 ; Vol. 81, No. 1. pp. 21-24.
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