Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population

Guidance for clinicians to prevent coronary heart disease

Børge G. Nordestgaard, M. John Chapman, Steve E. Humphries, Henry N. Ginsberg, Luis Masana, Olivier S. Descamps, Olov Wiklund, Robert A. Hegele, Frederick J. Raal, Joep C. Defesche, Albert Wiegman, Raul D. Santos, Gerald F. Watts, Klaus G. Parhofer, G. Kees Hovingh, Petri T. Kovanen, Catherine Boileau, Maurizio Averna, Jan Borén, Eric Bruckert & 8 others Alberico L. Catapano, Jan Albert Kuivenhoven, Päivi Pajukanta, Kausik Ray, Anton F H Stalenhoef, Erik Stroes, Marja Riitta Taskinen, Anne Tybjærg-Hansen

Research output: Contribution to journalArticle

1074 Citations (Scopus)

Abstract

Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD). Methods and results Of the theoretical estimated prevalence of 1/500 for heterozygous FH,

Original languageEnglish
JournalEuropean Heart Journal
Volume34
Issue number45
DOIs
Publication statusPublished - Dec 1 2013

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Hyperlipoproteinemia Type II
Coronary Disease
Population

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Cholesterol
  • Coronary heart disease
  • Low-density lipoprotein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., ... Tybjærg-Hansen, A. (2013). Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease. European Heart Journal, 34(45). https://doi.org/10.1093/eurheartj/eht273

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population : Guidance for clinicians to prevent coronary heart disease. / Nordestgaard, Børge G.; Chapman, M. John; Humphries, Steve E.; Ginsberg, Henry N.; Masana, Luis; Descamps, Olivier S.; Wiklund, Olov; Hegele, Robert A.; Raal, Frederick J.; Defesche, Joep C.; Wiegman, Albert; Santos, Raul D.; Watts, Gerald F.; Parhofer, Klaus G.; Hovingh, G. Kees; Kovanen, Petri T.; Boileau, Catherine; Averna, Maurizio; Borén, Jan; Bruckert, Eric; Catapano, Alberico L.; Kuivenhoven, Jan Albert; Pajukanta, Päivi; Ray, Kausik; Stalenhoef, Anton F H; Stroes, Erik; Taskinen, Marja Riitta; Tybjærg-Hansen, Anne.

In: European Heart Journal, Vol. 34, No. 45, 01.12.2013.

Research output: Contribution to journalArticle

Nordestgaard, BG, Chapman, MJ, Humphries, SE, Ginsberg, HN, Masana, L, Descamps, OS, Wiklund, O, Hegele, RA, Raal, FJ, Defesche, JC, Wiegman, A, Santos, RD, Watts, GF, Parhofer, KG, Hovingh, GK, Kovanen, PT, Boileau, C, Averna, M, Borén, J, Bruckert, E, Catapano, AL, Kuivenhoven, JA, Pajukanta, P, Ray, K, Stalenhoef, AFH, Stroes, E, Taskinen, MR & Tybjærg-Hansen, A 2013, 'Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease', European Heart Journal, vol. 34, no. 45. https://doi.org/10.1093/eurheartj/eht273
Nordestgaard, Børge G. ; Chapman, M. John ; Humphries, Steve E. ; Ginsberg, Henry N. ; Masana, Luis ; Descamps, Olivier S. ; Wiklund, Olov ; Hegele, Robert A. ; Raal, Frederick J. ; Defesche, Joep C. ; Wiegman, Albert ; Santos, Raul D. ; Watts, Gerald F. ; Parhofer, Klaus G. ; Hovingh, G. Kees ; Kovanen, Petri T. ; Boileau, Catherine ; Averna, Maurizio ; Borén, Jan ; Bruckert, Eric ; Catapano, Alberico L. ; Kuivenhoven, Jan Albert ; Pajukanta, Päivi ; Ray, Kausik ; Stalenhoef, Anton F H ; Stroes, Erik ; Taskinen, Marja Riitta ; Tybjærg-Hansen, Anne. / Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population : Guidance for clinicians to prevent coronary heart disease. In: European Heart Journal. 2013 ; Vol. 34, No. 45.
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