Familial papillary thyroid microcarcinoma: A new clinical entity

Giovanni Lupoli, Giovanni Vitale, Michèle Caraglia, Maria Rosa Fittipaldi, Alberto Abbruzzese, Pierosandro Tagliaferri, Angelo Raffaele Bianco

Research output: Contribution to journalArticle

Abstract

Background. Familial, non-medullary thyroid carcinoma is more aggressive than the sporadic form. We wanted to find out whether papillary thyroid microcarcinoma also occurs in a familial pattern, and, if so, to identify specific clinical and prognostic features. Methods. We reviewed the clinical records of 119 patients with papillary thyroid microcarcinoma. Familial occurrence, together with clinical presentation, surgical treatment, pathological characteristics, and follow-up were recorded. Findings. We identified a family history of thyroid carcinoma in seven patients. The tumour was multifocal in five patients, bilateral in three, and vascular invasion occurred in three of the seven patients. Lymph-node metastases were found in four patients. Three patients had a recurrence and one patient with pulmonary metastases died within 11 months. Interpretation. We identified familial occurrence in 5.9% of cases of papillary thyroid microcarcinoma. The unfavourable behaviour in the familal form of papillary thyroid microcarcinoma suggests that radical treatment and careful follow-up are warranted.

Original languageEnglish
Pages (from-to)637-639
Number of pages3
JournalLancet
Volume353
Issue number9153
DOIs
Publication statusPublished - Feb 20 1999

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Neoplasm Metastasis
Papillary Thyroid Microcarcinoma
Thyroid Neoplasms
Blood Vessels
Lymph Nodes
Recurrence
Lung
Therapeutics
Neoplasms
Familial medullary thyroid carcinoma

ASJC Scopus subject areas

  • Medicine(all)

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Lupoli, G., Vitale, G., Caraglia, M., Fittipaldi, M. R., Abbruzzese, A., Tagliaferri, P., & Bianco, A. R. (1999). Familial papillary thyroid microcarcinoma: A new clinical entity. Lancet, 353(9153), 637-639. https://doi.org/10.1016/S0140-6736(98)08004-0

Familial papillary thyroid microcarcinoma : A new clinical entity. / Lupoli, Giovanni; Vitale, Giovanni; Caraglia, Michèle; Fittipaldi, Maria Rosa; Abbruzzese, Alberto; Tagliaferri, Pierosandro; Bianco, Angelo Raffaele.

In: Lancet, Vol. 353, No. 9153, 20.02.1999, p. 637-639.

Research output: Contribution to journalArticle

Lupoli, G, Vitale, G, Caraglia, M, Fittipaldi, MR, Abbruzzese, A, Tagliaferri, P & Bianco, AR 1999, 'Familial papillary thyroid microcarcinoma: A new clinical entity', Lancet, vol. 353, no. 9153, pp. 637-639. https://doi.org/10.1016/S0140-6736(98)08004-0
Lupoli G, Vitale G, Caraglia M, Fittipaldi MR, Abbruzzese A, Tagliaferri P et al. Familial papillary thyroid microcarcinoma: A new clinical entity. Lancet. 1999 Feb 20;353(9153):637-639. https://doi.org/10.1016/S0140-6736(98)08004-0
Lupoli, Giovanni ; Vitale, Giovanni ; Caraglia, Michèle ; Fittipaldi, Maria Rosa ; Abbruzzese, Alberto ; Tagliaferri, Pierosandro ; Bianco, Angelo Raffaele. / Familial papillary thyroid microcarcinoma : A new clinical entity. In: Lancet. 1999 ; Vol. 353, No. 9153. pp. 637-639.
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