Familial papillary thyroid microcarcinoma: A new clinical entity

Giovanni Lupoli, Giovanni Vitale, Michèle Caraglia, Maria Rosa Fittipaldi, Alberto Abbruzzese, Pierosandro Tagliaferri, Angelo Raffaele Bianco

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Familial, non-medullary thyroid carcinoma is more aggressive than the sporadic form. We wanted to find out whether papillary thyroid microcarcinoma also occurs in a familial pattern, and, if so, to identify specific clinical and prognostic features. Methods. We reviewed the clinical records of 119 patients with papillary thyroid microcarcinoma. Familial occurrence, together with clinical presentation, surgical treatment, pathological characteristics, and follow-up were recorded. Findings. We identified a family history of thyroid carcinoma in seven patients. The tumour was multifocal in five patients, bilateral in three, and vascular invasion occurred in three of the seven patients. Lymph-node metastases were found in four patients. Three patients had a recurrence and one patient with pulmonary metastases died within 11 months. Interpretation. We identified familial occurrence in 5.9% of cases of papillary thyroid microcarcinoma. The unfavourable behaviour in the familal form of papillary thyroid microcarcinoma suggests that radical treatment and careful follow-up are warranted.

Original languageEnglish
Pages (from-to)637-639
Number of pages3
JournalLancet
Volume353
Issue number9153
DOIs
Publication statusPublished - Feb 20 1999

ASJC Scopus subject areas

  • Medicine(all)

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