Family cancer history and risk of brain tumors in children

Results of the SEARCH international brain tumor study

Susan Searles Nielsen, Beth A. Mueller, Susan Preston-Martin, Elizabeth A. Holly, Julian Little, Paige M. Bracci, Margaret McCredie, Rafael Peris-Bonet, Sylvaine Cordier, Graziella Filippini, Flora Lubin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study. Methods: Cancers in children's first- and second-degree relatives were ascertained by interview with parents of 620 children with astroglial tumors, 255 with primitive neuroectodermal tumors, 324 with other CBTs, and 2,218 controls from Australia, Canada, France, Israel, Italy, Spain, and the US. These were used with histories of neurofibromatosis or tuberous sclerosis to exclude in subanalyses children with Li-Fraumeni or other hereditary syndromes predisposing to brain tumors. Results: A first- or second-degree relative of 4% of children with astroglial tumors, 6% with PNET, 5% with other CBTs, and 5% of controls had had a brain tumor. Any potential differences were statistically non-significant, including when focusing on relatives diagnosed in childhood. In the US, where anatomical sites of relatives' other cancers were known, CBT occurrence was not associated with any other specific site. Results were not markedly altered by exclusion of children with hereditary syndromes. Conclusion: Consistent with most prior studies using these methods, we observed no strong relationship between CBT occurrence and cancers in family members.

Original languageEnglish
Pages (from-to)641-648
Number of pages8
JournalCancer Causes and Control
Volume19
Issue number6
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Brain Neoplasms
Neoplasms
Primitive Neuroectodermal Tumors
Neurofibromatoses
Tuberous Sclerosis
Israel
Spain
Italy
France
Canada
Case-Control Studies
Parents
Interviews

Keywords

  • Children
  • Heredity
  • Nervous system neoplasms

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Searles Nielsen, S., Mueller, B. A., Preston-Martin, S., Holly, E. A., Little, J., Bracci, P. M., ... Lubin, F. (2008). Family cancer history and risk of brain tumors in children: Results of the SEARCH international brain tumor study. Cancer Causes and Control, 19(6), 641-648. https://doi.org/10.1007/s10552-008-9128-7

Family cancer history and risk of brain tumors in children : Results of the SEARCH international brain tumor study. / Searles Nielsen, Susan; Mueller, Beth A.; Preston-Martin, Susan; Holly, Elizabeth A.; Little, Julian; Bracci, Paige M.; McCredie, Margaret; Peris-Bonet, Rafael; Cordier, Sylvaine; Filippini, Graziella; Lubin, Flora.

In: Cancer Causes and Control, Vol. 19, No. 6, 08.2008, p. 641-648.

Research output: Contribution to journalArticle

Searles Nielsen, S, Mueller, BA, Preston-Martin, S, Holly, EA, Little, J, Bracci, PM, McCredie, M, Peris-Bonet, R, Cordier, S, Filippini, G & Lubin, F 2008, 'Family cancer history and risk of brain tumors in children: Results of the SEARCH international brain tumor study', Cancer Causes and Control, vol. 19, no. 6, pp. 641-648. https://doi.org/10.1007/s10552-008-9128-7
Searles Nielsen, Susan ; Mueller, Beth A. ; Preston-Martin, Susan ; Holly, Elizabeth A. ; Little, Julian ; Bracci, Paige M. ; McCredie, Margaret ; Peris-Bonet, Rafael ; Cordier, Sylvaine ; Filippini, Graziella ; Lubin, Flora. / Family cancer history and risk of brain tumors in children : Results of the SEARCH international brain tumor study. In: Cancer Causes and Control. 2008 ; Vol. 19, No. 6. pp. 641-648.
@article{15f3088f31a64c58a0088417901851f0,
title = "Family cancer history and risk of brain tumors in children: Results of the SEARCH international brain tumor study",
abstract = "Objective: To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study. Methods: Cancers in children's first- and second-degree relatives were ascertained by interview with parents of 620 children with astroglial tumors, 255 with primitive neuroectodermal tumors, 324 with other CBTs, and 2,218 controls from Australia, Canada, France, Israel, Italy, Spain, and the US. These were used with histories of neurofibromatosis or tuberous sclerosis to exclude in subanalyses children with Li-Fraumeni or other hereditary syndromes predisposing to brain tumors. Results: A first- or second-degree relative of 4{\%} of children with astroglial tumors, 6{\%} with PNET, 5{\%} with other CBTs, and 5{\%} of controls had had a brain tumor. Any potential differences were statistically non-significant, including when focusing on relatives diagnosed in childhood. In the US, where anatomical sites of relatives' other cancers were known, CBT occurrence was not associated with any other specific site. Results were not markedly altered by exclusion of children with hereditary syndromes. Conclusion: Consistent with most prior studies using these methods, we observed no strong relationship between CBT occurrence and cancers in family members.",
keywords = "Children, Heredity, Nervous system neoplasms",
author = "{Searles Nielsen}, Susan and Mueller, {Beth A.} and Susan Preston-Martin and Holly, {Elizabeth A.} and Julian Little and Bracci, {Paige M.} and Margaret McCredie and Rafael Peris-Bonet and Sylvaine Cordier and Graziella Filippini and Flora Lubin",
year = "2008",
month = "8",
doi = "10.1007/s10552-008-9128-7",
language = "English",
volume = "19",
pages = "641--648",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer International Publishing AG",
number = "6",

}

TY - JOUR

T1 - Family cancer history and risk of brain tumors in children

T2 - Results of the SEARCH international brain tumor study

AU - Searles Nielsen, Susan

AU - Mueller, Beth A.

AU - Preston-Martin, Susan

AU - Holly, Elizabeth A.

AU - Little, Julian

AU - Bracci, Paige M.

AU - McCredie, Margaret

AU - Peris-Bonet, Rafael

AU - Cordier, Sylvaine

AU - Filippini, Graziella

AU - Lubin, Flora

PY - 2008/8

Y1 - 2008/8

N2 - Objective: To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study. Methods: Cancers in children's first- and second-degree relatives were ascertained by interview with parents of 620 children with astroglial tumors, 255 with primitive neuroectodermal tumors, 324 with other CBTs, and 2,218 controls from Australia, Canada, France, Israel, Italy, Spain, and the US. These were used with histories of neurofibromatosis or tuberous sclerosis to exclude in subanalyses children with Li-Fraumeni or other hereditary syndromes predisposing to brain tumors. Results: A first- or second-degree relative of 4% of children with astroglial tumors, 6% with PNET, 5% with other CBTs, and 5% of controls had had a brain tumor. Any potential differences were statistically non-significant, including when focusing on relatives diagnosed in childhood. In the US, where anatomical sites of relatives' other cancers were known, CBT occurrence was not associated with any other specific site. Results were not markedly altered by exclusion of children with hereditary syndromes. Conclusion: Consistent with most prior studies using these methods, we observed no strong relationship between CBT occurrence and cancers in family members.

AB - Objective: To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study. Methods: Cancers in children's first- and second-degree relatives were ascertained by interview with parents of 620 children with astroglial tumors, 255 with primitive neuroectodermal tumors, 324 with other CBTs, and 2,218 controls from Australia, Canada, France, Israel, Italy, Spain, and the US. These were used with histories of neurofibromatosis or tuberous sclerosis to exclude in subanalyses children with Li-Fraumeni or other hereditary syndromes predisposing to brain tumors. Results: A first- or second-degree relative of 4% of children with astroglial tumors, 6% with PNET, 5% with other CBTs, and 5% of controls had had a brain tumor. Any potential differences were statistically non-significant, including when focusing on relatives diagnosed in childhood. In the US, where anatomical sites of relatives' other cancers were known, CBT occurrence was not associated with any other specific site. Results were not markedly altered by exclusion of children with hereditary syndromes. Conclusion: Consistent with most prior studies using these methods, we observed no strong relationship between CBT occurrence and cancers in family members.

KW - Children

KW - Heredity

KW - Nervous system neoplasms

UR - http://www.scopus.com/inward/record.url?scp=46449099445&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46449099445&partnerID=8YFLogxK

U2 - 10.1007/s10552-008-9128-7

DO - 10.1007/s10552-008-9128-7

M3 - Article

VL - 19

SP - 641

EP - 648

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 6

ER -