Abstract
Objective: To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study. Methods: Cancers in children's first- and second-degree relatives were ascertained by interview with parents of 620 children with astroglial tumors, 255 with primitive neuroectodermal tumors, 324 with other CBTs, and 2,218 controls from Australia, Canada, France, Israel, Italy, Spain, and the US. These were used with histories of neurofibromatosis or tuberous sclerosis to exclude in subanalyses children with Li-Fraumeni or other hereditary syndromes predisposing to brain tumors. Results: A first- or second-degree relative of 4% of children with astroglial tumors, 6% with PNET, 5% with other CBTs, and 5% of controls had had a brain tumor. Any potential differences were statistically non-significant, including when focusing on relatives diagnosed in childhood. In the US, where anatomical sites of relatives' other cancers were known, CBT occurrence was not associated with any other specific site. Results were not markedly altered by exclusion of children with hereditary syndromes. Conclusion: Consistent with most prior studies using these methods, we observed no strong relationship between CBT occurrence and cancers in family members.
| Original language | English |
|---|---|
| Pages (from-to) | 641-648 |
| Number of pages | 8 |
| Journal | Cancer Causes and Control |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Aug 2008 |
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Keywords
- Children
- Heredity
- Nervous system neoplasms
ASJC Scopus subject areas
- Oncology
- Epidemiology
- Cancer Research
Cite this
Family cancer history and risk of brain tumors in children : Results of the SEARCH international brain tumor study. / Searles Nielsen, Susan; Mueller, Beth A.; Preston-Martin, Susan; Holly, Elizabeth A.; Little, Julian; Bracci, Paige M.; McCredie, Margaret; Peris-Bonet, Rafael; Cordier, Sylvaine; Filippini, Graziella; Lubin, Flora.
In: Cancer Causes and Control, Vol. 19, No. 6, 08.2008, p. 641-648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Family cancer history and risk of brain tumors in children
T2 - Results of the SEARCH international brain tumor study
AU - Searles Nielsen, Susan
AU - Mueller, Beth A.
AU - Preston-Martin, Susan
AU - Holly, Elizabeth A.
AU - Little, Julian
AU - Bracci, Paige M.
AU - McCredie, Margaret
AU - Peris-Bonet, Rafael
AU - Cordier, Sylvaine
AU - Filippini, Graziella
AU - Lubin, Flora
PY - 2008/8
Y1 - 2008/8
N2 - Objective: To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study. Methods: Cancers in children's first- and second-degree relatives were ascertained by interview with parents of 620 children with astroglial tumors, 255 with primitive neuroectodermal tumors, 324 with other CBTs, and 2,218 controls from Australia, Canada, France, Israel, Italy, Spain, and the US. These were used with histories of neurofibromatosis or tuberous sclerosis to exclude in subanalyses children with Li-Fraumeni or other hereditary syndromes predisposing to brain tumors. Results: A first- or second-degree relative of 4% of children with astroglial tumors, 6% with PNET, 5% with other CBTs, and 5% of controls had had a brain tumor. Any potential differences were statistically non-significant, including when focusing on relatives diagnosed in childhood. In the US, where anatomical sites of relatives' other cancers were known, CBT occurrence was not associated with any other specific site. Results were not markedly altered by exclusion of children with hereditary syndromes. Conclusion: Consistent with most prior studies using these methods, we observed no strong relationship between CBT occurrence and cancers in family members.
AB - Objective: To examine whether childhood brain tumors (CBTs) are associated with a family history of brain tumors or other cancers in an international case-control study. Methods: Cancers in children's first- and second-degree relatives were ascertained by interview with parents of 620 children with astroglial tumors, 255 with primitive neuroectodermal tumors, 324 with other CBTs, and 2,218 controls from Australia, Canada, France, Israel, Italy, Spain, and the US. These were used with histories of neurofibromatosis or tuberous sclerosis to exclude in subanalyses children with Li-Fraumeni or other hereditary syndromes predisposing to brain tumors. Results: A first- or second-degree relative of 4% of children with astroglial tumors, 6% with PNET, 5% with other CBTs, and 5% of controls had had a brain tumor. Any potential differences were statistically non-significant, including when focusing on relatives diagnosed in childhood. In the US, where anatomical sites of relatives' other cancers were known, CBT occurrence was not associated with any other specific site. Results were not markedly altered by exclusion of children with hereditary syndromes. Conclusion: Consistent with most prior studies using these methods, we observed no strong relationship between CBT occurrence and cancers in family members.
KW - Children
KW - Heredity
KW - Nervous system neoplasms
UR - http://www.scopus.com/inward/record.url?scp=46449099445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46449099445&partnerID=8YFLogxK
U2 - 10.1007/s10552-008-9128-7
DO - 10.1007/s10552-008-9128-7
M3 - Article
VL - 19
SP - 641
EP - 648
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 6
ER -